新发传染病电子杂志2025，Vol.10Issue(2)：40-46,7.DOI:10.19871/j.cnki.xfcrbzz.2025.02.008
结核性毁损肺相关肺动脉高压患者的临床特点分析
Analysis of clinical characteristics of patients with TB-damaged pulmonary hypertension
摘要
Abstract
Objective To analyze the laboratory tests,imaging,echocardiography and hemodynamic characteristics of pulmonary hypertension(PH)associated with tuberculous lung destruction,and to provide clinical evidence for the diagnosis and treatment of such patients.Method A retrospective collection was made of 44 patients with PH associated with tuberculous lung destruction who were hospitalized at Chongqing Public Health Medical Treatment Center from July 1,2023 to June 30,2024.Basic demographic information,the extent of lung destruction,laboratory tests,imaging,echocardiography and right heart catheterization data of the patients were collected,and the clinical characteristics of the patients were analyzed.Result The age of patients with PH associated with tuberculous lung destruction was(56.64±11.10)years,and the body mass index(BMI)was(17.95±2.87)kg/m2.The proportion of male patients was 2.1 times that of female patients.D-dimer was 1.06(0.42,2.02)mg/L,and N-terminal pro-B-type natriuretic peptide(NT-proBNP)was 453.00(191.00,1178.00)pg/ml.The left lung was the most frequently involved site of destruction(54.55%).Bronchiectasis was present in 29 cases(65.91%),and pulmonary cavities in 23 cases(52.27%).Pleural thickening was present in 43 cases(97.73%).The estimated pulmonary artery systolic pressure by echocardiography was 53.0(40.25,60.75)mmHg.The diameter of the main pulmonary artery was wider in female patients than in male patients(P＜0.05).The mean pulmonary artery pressure(mPAP)of the 12 patients who underwent right heart catheterization was 31.00(29.00,35.25)mmHg,and the pulmonary vascular resistance(PVR)was 6.02(3.87,8.91)WU.Conclusion Patients with PH associated with tuberculous lung destruction have a low BMI level,a higher proportion of male patients than female patients,elevated D-dimer and NT-proBNP,and the destruction often involves the left lung.They also have multiple lung destructions,and hemodynamic indicators suggest a significant increase in PVR.关键词
结核/毁损肺/肺动脉高压/临床特点Key words
Tuberculosis/Destroyed lung/Pulmonary hypertension/Clinical characteristics分类
临床医学引用本文复制引用
孙楠楠,熊艳美,杨松,岑武强,刘雪艳..结核性毁损肺相关肺动脉高压患者的临床特点分析[J].新发传染病电子杂志,2025,10(2):40-46,7.基金项目
重庆市沙坪坝区科技项目(2024060) （2024060）
