摘要
Abstract
Objective To investigate the predictive value of preoperative neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),prognostic nutritional index(PNI),and prealbumin(PALB)for prognosis in patients under-going radical resection for esophageal cancer.Methods A total of 81 patients with esophageal cancer were selected,and their NLR,PLR,PNI,and PALB were measured one week prior to radical esophagectomy.The patients were followed up for three years,and they were divided into recurrence(39 cases)and non-recurrence(42 cases)groups based on their re-currence status.The above markers were compared between the two groups.Results The recurrence group had larger tumor diameter,and a higher proportion of TNM stagesⅡ,Ⅲ,Ⅳand lymph node metastases compared with the non-recurrence group(P＜0.05).The PNI and PALB in the recurrence group were lower than those in the non-recurrence group(P＜0.05),while the PLR and NLR were higher(P＜0.05).Univariate Cox regression analysis indicated that tumor differentia-tion,tumor diameter,NLR,PLR,PALB,and PNI were associated with prognosis in esophageal cancer(P＜0.05).Multi-variate Cox regression analysis revealed that NLR,PLR,PNI,and PALB were all factors affecting prognosis(P＜0.05).ROC curve analysis of NLR,PLR,PNI,PALB,and combined detection found that PALB had the highest sensitivity,while NLR and PNI had the highest specificity when tested individually.The predictive value was maximized with combined detection,achieving an AUC of 0.853,though no significant improvement in sensitivity or specificity was noted.Conclu-sion Preoperative NLR,PLR,PALB,and PNI have predictive value for prognosis in patients with esophageal cancer un-dergoing esophagectomy.Combined detection of these four markers can enhance the accuracy of prognostic prediction,but would not significantly improve sensitivity and specificity.关键词
食管癌/中性粒细胞与淋巴细胞比值/血小板与淋巴细胞比值/预后营养指数/前白蛋白/预后Key words
Esophageal cancer/Neutrophil to lymphocyte ratio/Platelet to lymphocyte ratio/Prognostic nutritional index Prealbumin Prognosis
