中国肛肠病杂志2025，Vol.45Issue(5)：21-24,4.
粪便SDC2基因甲基化检测在进展期肠道肿瘤筛查中的应用价值
Application Value of Fecal SDC2 Gene Methylation Detection in Screening of Advanced Intestinal Tumors
张莎娜 1安吾麦 1吴晓红 1胥俊越 1赵亚虹 1李弈 1贾兴旺1
作者信息
摘要
Abstract
Objective To compare the diagnostic efficacy of fecal Syndecan-2(SDC2)gene methylation detection with fecal occult blood test(FOBT)and serum carcinoembryonic antigen(CEA)detection for colorectal cancer(CRC)and advanced adenoma,and to evaluate the diagnostic value of fecal SDC2 gene methylation detection for CRC and advanced adenoma.Methods A total of 6,881 subjects were included for fecal SDC2 gene methylation detection.Those with positive initial screening results further underwent serum CEA,FOBT tests and total colonoscopy.Pathological diagnosis was used as the gold standard to e-valuate the screening performance.The positive rate and positive predictive value(PPV)of fecal SDC2 gene methylation detection as the initial screening for CRC were observed.Results There were 463 cases(6.7％,463/6881)with positive initial screening results for fecal SDC2 gene methylation.Among them,85 cases(18.4％,85/463)of the positive subjects completed colonoscopy,and 75 cases(88.2％)of intestinal lesions were detected,including 21 cases of CRC,23 cases of advanced adenoma,25 cases of non-advanced adenoma and 6 cases of polyps.The PPV of fecal SDC2 gene methylation detection for CRC was 24.7％(21/85),and the overall PPV for intestinal tumors was 88.2％(69/85).The sensitivities of serum CEA for CRC and advanced adenoma were 57.1％and 4.3％respectively,and those of FOBT were 42.8％and 8.7％respectively.The specificities of both were 90.2％.Conclusion The screening efficacy of fecal SDC2 gene methylation detection for advanced intestinal tumors is significantly better than that of serum CEA and FOBT,and it can be used as the preferred strategy for the early screening of CRC.关键词
结直肠癌/筛查/粪便SDC2基因甲基化Key words
Colorectal cancer/Screening/Fecal Syndecan-2(SDC2)gene methylation引用本文复制引用
张莎娜,安吾麦,吴晓红,胥俊越,赵亚虹,李弈,贾兴旺..粪便SDC2基因甲基化检测在进展期肠道肿瘤筛查中的应用价值[J].中国肛肠病杂志,2025,45(5):21-24,4.
