摘要
Abstract
Objective To explore the efficacy of lysine hydrochloride and zinc gluconate granules com-bined with interferon in adjuvant treatment for infantile rotavirus enteritis(IRVE).Methods Total 80 children with rotavirus enteritis(RVE)were randomly divided into two groups,40 cases each.One group received conventional symptomatic supportive treatment(control group),while the other group was trea-ted with lysine hydrochloride and zinc gluconate granules and recombinant human interferon α1b in addi-tion to conventional symptomatic treatment(observation group).The clinical efficacy,intestinal mucosal barrier function-related indicators[serum diamine oxidase(DAO),D-lactate],levels of microinflammato-ry markers(IL-1β,IL-6,CRP,TNF-α),and the counts of major intestinal flora(Lactobacillus,Bifidobac-terium,Escherichia coli)before and after treatment were compared between the two groups.Results The total effective rate in the observation group(95.00％)was higher than that in the control group(80.00％)(P＜0.05).The serum levels of DAO,D-lactate,IL-6,IL-1β,TNF-α,and CRP in both groups decreased after treatment compared with those before treatment(P＜0.05).Post-treatment com-parison between the two groups showed that the observation group had lower levels of these indicators(P＜0.05).After treatment,the contents of intestinal Lactobacillus and Bifidobacterium increased signifi-cantly(P＜0.05),while the content of Escherichia coli decreased significantly(P＜0.05)in both groups.After treatment,the observation group had significantly higher contents of Lactobacillus and Bifidobacterium(P＜0.05)and lower content of Escherichia coli(P＜0.05)than the control group.Conclusion The adjuvant treatment of lysine hydrochloride and zinc gluconate granules and interferon in addition to the conventional symptomatic treatment in IRVE,can promote intestinal barrier repair,inhibit inflammatory responses,and regulate intestinal flora.关键词
轮状病毒性肠炎/赖氨葡锌颗粒/干扰素/肠黏膜屏障功能/肠道菌群/炎症反应Key words
Rotavirus enteritis/Lysine hydrochloride and zinc gluconate granules/Interferon/Intestinal mucosal barrier function/Intestinal flora/Inflammatory response
