中国临床药理学杂志2025，Vol.41Issue(8)：1144-1151,8.DOI:10.13699/j.cnki.1001-6821.2025.08.017
2021-2023年西北地区某三甲医院临床病原菌分离及耐药性监测
Surveillance of antimicrobial resistance among bacterial strains isolated from a Northwest tertiary teaching hospital in 2021-2023
摘要
Abstract
Objective To analyze the antimicrobial sensitivity against clinical isolates in the first affiliated hospital of air force medical university in the past three years.Methods The nonduplicate clinical isolates were collected in 2021-2023,identification and drug sensitivity test were performed by using VITEK2-compact automatic bacteria identification system.The data was analyzed using WHONET 5.6 software and interpreted according to the Clinical and Laboratory Standards Institute(CLSI)2023 breakpoints.Results A total of 20 536 clinical isolates were collected,of which 28.78％were gram-positive,58.64％were gram-negative,11.94％were fungi and 0.64％were anaerobe.The prevalence of methicillin-resistant strains in Staphylococcus aureus and coagulase-negative Staphylococcus were 49.11％and 73.06％,respectively.No Staphylococcus resistant to vancomycin,linezolid,or tigecycline was detected.The resistance rates of Enterococcus faecium to most antimicrobial agents were much higher than Enterococcus faecalis.8 strains of vancomycin-resistant Enterococcus faecium were isolated,and a few linezolid-resistant strains were identiffed in both species.The prevalence of penicillin-susceptible Streptococcus pneumoniae(PSSP)was 95.85％.The resistance rate to carbapenems was 0.2％to 12.8％in Enterobacterales species,and the detection rate of carbapenem-resistant Enterobacteriaceae(CRE)was 6.6％,with Klebsiella pneumoniae accounting for 66.53％.The resistance rates of Acinetobacter spp to imipenem and meropenem were 75.3％and 76.7％,respectively.Meanwhile,the rates of Pseudomonas aeruginosa were 22.9％and 19.9％respectively.Conclusion The antimicrobial resistance of clinical isolates in our hospital is still serious.All relevant departments should strengthen the monitoring of bacterial resistance in order to curb the development and spread of bacterial resistance.关键词
细菌耐药监测/病原菌/耐药性/流行病学Key words
antimicrobial resistance surveillance/pathogenic bacteria/resistance/epidemiology分类
药学引用本文复制引用
周珊,刘昊,孔美娟,康蓓佩,白露,周柯,刘家云..2021-2023年西北地区某三甲医院临床病原菌分离及耐药性监测[J].中国临床药理学杂志,2025,41(8):1144-1151,8.基金项目
陕西省自然科学基金资助项目(2020JQ-459) （2020JQ-459）
