中国临床药理学杂志2025，Vol.41Issue(8)：1175-1179,5.DOI:10.13699/j.cnki.1001-6821.2025.06.022
基于生物信息学探索ATF3参与高血压肾病细胞衰老的相关机制
Exploration the mechanism of ATF3 participating in cell senescence of hypertensive nephropathy based on bioinformatics analysis
摘要
Abstract
Objective To study the possible mechanism and related signaling pathway of cell senescence in hypertensive nephropathy with the help of bioinformatics.Methods The microarray data GSE37455 was downloaded from the gene expression database,and the data was merged with R software to remove the batch effect,so as to obtain differentially expressed genes.Cell aging genes were obtained from the CellAge database,and differential genes related to cell aging were obtained through R package"ggVennDiagram".Gene interaction network string database was imported to obtain protein protein interaction(PPI)network map,and Cytoscape3.8.0 software was used to mine core differential genes.The function and pathway of core differential genes were analyzed by gene ontology(GO),Kyoto encyclopedia of genes and genomes(KEGG)and gene set enrichment analysis(GSEA).Results A total of 41 differential genes were obtained,including 32 up-regulated genes and 9 down-regulated genes.Four differential genes related to cell senescence were obtained after intersection.The core differential gene-activated transcription factor 3(ATF3)was obtained by PPI analysis and Cytoscape treatment.GSEA analysis showed that cell senescence might play a role in hypertensive nephropathy through the thermogenesis of mitochondrial uncoupling protein 1 and the signal transduction of type Ⅰ interferon response(TYPE-Ⅰ-IFN).Conclusion Cellular senescence may play a role in hypertensive nephropathy through pathways such as mitochondrial uncoupling protein-1 thermogenesis and TYPE-Ⅰ-IFN signaling,which provides a therapeutic target for the study of hypertensive nephropathy.关键词
高血压肾病/细胞衰老/差异表达基因/生物信息学/作用机制Key words
hypertensive nephropathy/cellular senescence/differentially expressed genes/bioinformatics/mechanism of action分类
医药卫生引用本文复制引用
陈瑜,邱志维,罗鑫,王佳佳,向倩..基于生物信息学探索ATF3参与高血压肾病细胞衰老的相关机制[J].中国临床药理学杂志,2025,41(8):1175-1179,5.基金项目
国家自然科学基金资助项目(82300799) （82300799）
