中国临床药理学杂志2025，Vol.41Issue(8)：1186-1190,5.DOI:10.13699/j.cnki.1001-6821.2025.08.024
丁苯酞在帕金森病中的临床研究与作用机制现状
Research status of clinical and mechanistic on butylphthalide for Parkinson's disease
摘要
Abstract
Parkinson's disease(PD),a highly disabling neurodegenerative disorder,poses significant clinical challenges in both prevention and therapeutic intervention.Butylphthalide(NBP),a small-molecule compound derived from celery seeds,has garnered considerable attention due to its remarkable neuroprotective properties.This article systematically reviews recent studies,demonstrating that NBP not only ameliorates motor and non-motor symptoms in PD patients but also slows disease progression through modulation of neuroinflammation and mitochondrial function.By integrating clinical evidence with advances in molecular mechanism research,it provides a scientific foundation for in-depth investigation of NBP-based PD management and development of novel therapeutics.关键词
丁苯酞/帕金森病/神经炎症/线粒体自噬/铁死亡Key words
butylphthalide/Parkinson's disease/neuroinflammation/mitochondrial autophagy/ferroptosis分类
医药卫生引用本文复制引用
于淼,张重阳,孙潇,罗云,舒尊鹏,孙晓波,陈艳芬..丁苯酞在帕金森病中的临床研究与作用机制现状[J].中国临床药理学杂志,2025,41(8):1186-1190,5.基金项目
国家重点研发计划中医药现代化研究重点专项基金资助项目(2022YFC3501802) （2022YFC3501802）
