中国临床药理学杂志2025，Vol.41Issue(8)：1191-1195,5.DOI:10.13699/j.cnki.1001-6821.2025.08.025
中药调控自噬-凋亡平衡相关信号通路抗肿瘤作用的研究现状
Research status of the antitumor effects of traditional Chinese medicine on regulating autophagy and apoptosis balance related signaling pathways
摘要
Abstract
Surgery,chemoradiotherapy are the conventional methods of clinical treatment of tumor,due to adverse reactions,drug resistance and other problems,the prognosis and survival are poor.Due to its characteristics of stable action with little toxic side effects and multi-channel and multi-target comprehensive regulation,traditional Chinese medicine has been widely concerned and recognized in anti-tumor.Autophagy and apoptosis are two ways of programmed cell death,and the interaction between autophagy and apoptosis is crucial to the overall fate of cancer cells.The balance between autophagy and apoptosis contains the theory of Yin and Yang in traditional Chinese medicine,and has become an effective strategy for clinical treatment of cancer.This study summarized the mechanism of the signaling pathway involved in the regulation of autophagy and apoptosis balance and thus effectively inhibited the pathological process of tumors,in order to provide pharmacological basis and scientific reference for the development and clinical application of traditional Chinese medicine anti-tumor drugs.关键词
中药/信号通路/自噬-凋亡平衡/抗肿瘤Key words
traditional Chinese medicine/signaling pathway/autophagy and apoptosis balance/anti-tumor分类
医药卫生引用本文复制引用
马定财,王毛毛,王哲,张育贵,刘婷,高飞云,王彦钧,张转红,李越峰..中药调控自噬-凋亡平衡相关信号通路抗肿瘤作用的研究现状[J].中国临床药理学杂志,2025,41(8):1191-1195,5.基金项目
国家自然科学基金资助项目(82160750、81960713) （82160750、81960713）
甘肃省人才重点项目(中药炮制技术传承创新团队建设与示范推广) （中药炮制技术传承创新团队建设与示范推广）
甘肃省教育厅产业支撑计划基金资助项目(2021CYZC-21) （2021CYZC-21）
甘肃省科学技术厅-科技计划(创新基地与人才计划)基础研究创新群体基金资助项目(21JR7RA569) （创新基地与人才计划）
甘肃省联合科研基金资助项目(2024CYZC-41) （2024CYZC-41）
高校产业支撑基金资助项目(24JRRA882) （24JRRA882）
