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Integration of proteinogenic amino acids in the pathogenesis of schizophrenia

Michelle S.Carvalho Andrea Jackowski Rodrigo Affonseca Bressan Acioly Luiz Tavares Lacerda Nilson Antônio Assunção Mauricio Luis Sforca Silvana Aparecida Rocco Cristiane da Silva Silverio Marielle F.Queiroz Nunes Marcel Vella Nunes Marcelo P.Machado Adelino Leonardo Afonso dos Santos

医学前沿（英文）Issue(2)：123-135,13.

医学前沿（英文）Issue(2)：123-135,13.DOI:10.1002/med4.65

Integration of proteinogenic amino acids in the pathogenesis of schizophrenia

Michelle S.Carvalho ¹Andrea Jackowski ¹Rodrigo Affonseca Bressan ¹Acioly Luiz Tavares Lacerda ²Nilson Antônio Assunção ³Mauricio Luis Sforca ⁴Silvana Aparecida Rocco ⁴Cristiane da Silva Silverio ³Marielle F.Queiroz Nunes ²Marcel Vella Nunes ²Marcelo P.Machado Adelino ²Leonardo Afonso dos Santos²

作者信息

1. Interdisciplinary Laboratory of Clinical Neurosciences,Department of Psychiatry,Federal University of São Paulo,São Paulo,Brazil
2. Interdisciplinary Laboratory of Clinical Neurosciences,Department of Psychiatry,Federal University of São Paulo,São Paulo,Brazil||Bairral Institute,Itapira,São Paulo,Brazil
3. Department of Chemistry,Federal University of São Paulo,São Paulo,Brazil
4. Brazilian Biosciences National Laboratory,Brazilian Center for Research in Energy and Materials,Campinas,São Paulo,Brazil
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摘要

Abstract

Background:Schizophrenia(SCZ)is a severe mental disorder of multifac-torial origin in which the role of amino acids is relatively unknown.Based on the hypothesis that there is an imbalance in amino acid levels in individuals with SCZ compared with healthy controls(HCs),the aim of this study was to identify the 20 proteinogenic amino acids involved in protein synthesis. Methods:This study included 43 sex-and age-matched individuals:20 HCs and 23 with SCZ diagnosed using the Diagnostic and Statistical Manual of Mental Disorders criteria.Using proton nuclear magnetic resonance,we identified the serum levels of the 20 amino acids proteinogenic.We perform multivariate statistical exploratory analyzes to identify compounds,quantify,and identify the main biomarkers of SCZ. Results:We identified the serum levels of 19 of the 20 amino acids.Cysteine,the main precursor of glutathione,was not detected.Multivariate exploratory analysis identified lysine,Tryptophan(TRP),and glutamate as possible bio-markers of SCZ.Both lysine and TRP levels were lower and glutamate levels were higher in individuals with SCZ than in HCs.The observed reduction in plasma TRP levels in SCZ was attributed to the activation of the kynurenine pathway and has implications for serotonin synthesis.A strong positive cor-relation was observed between lysine and TRP,and a weak negative correla-tion between lysine and glutamate.This result is consistent with the lysine catalysis process because lysine degradation generates glutamate and favors an increase in dopamine. Conclusions:The results are consistent with the lysine catalysis process because lysine degradation generates glutamate and favors an increase in dopamine.We were unable to identify any studies suggesting a relationship between lysine catabolism and SCZ pathophysiology,but we recognize this association as innovative.

关键词

1H NMR/metabolomics/proteinogenic amino acids/schizophrenia

Key words

1H NMR/metabolomics/proteinogenic amino acids/schizophrenia

引用本文复制引用

Michelle S.Carvalho,Andrea Jackowski,Rodrigo Affonseca Bressan,Acioly Luiz Tavares Lacerda,Nilson Antônio Assunção,Mauricio Luis Sforca,Silvana Aparecida Rocco,Cristiane da Silva Silverio,Marielle F.Queiroz Nunes,Marcel Vella Nunes,Marcelo P.Machado Adelino,Leonardo Afonso dos Santos..Integration of proteinogenic amino acids in the pathogenesis of schizophrenia[J].医学前沿（英文）,2024,(2):123-135,13.

基金项目

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brazil(CAPES)-Finance Code 001 （CAPES）

医学前沿（英文）

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