中国免疫学杂志2025，Vol.41Issue(6)：1531-1536,后插1,7.DOI:10.3969/j.issn.1000-484X.2025.06.044
TPX2与肿瘤微环境的关系
Relationship between TPX2 with tumor microenvironment
摘要
Abstract
Tumor microenvironment(TME)is the living environment of tumor cells.The immune cells contained in TME are reprogrammed into tumor-promoting states due to various factors.Inhibiting this reprogramming effect of TME is an innovative strategy for treating tumors.As an essential factor in spindle assembly,TPX2 is considered to be a gene that promotes cancer cell proliferation and plays a role in cell response to replication stress.Highly expressed TPX2 in tumor cells promotes tumor growth through a variety of pathways,and these pathways can promote the tumor-promoting activity of immune cells in TME.Therefore,TPX2 may be a regulatory gene of TME.This paper discusses the possible mechanism of TPX2 involved in the regulation of TME by discussing the pathway medi-ated by TPX2 and the regulation of immune cells infiltrated in TME,and provides ideas for subsequent research directions.关键词
TPX2/肿瘤微环境/PI3K/WntKey words
TPX2/Tumor microenvironment/PI3K/Wnt分类
临床医学引用本文复制引用
吴钰,董海荣,苏秀兰..TPX2与肿瘤微环境的关系[J].中国免疫学杂志,2025,41(6):1531-1536,后插1,7.基金项目
国家自然科学基金项目(81960560). （81960560）
