中国体外循环杂志2025，Vol.23Issue(3)：258-262,268,6.DOI:10.13498/j.cnki.chin.j.ecc.2025.03.13
富集miR-29b的外泌体在心肌梗死后抑制心室重构的影响
Research on the role and mechanism of miR-29b-enriched exosomes in inhibiting post-myocardial infarction ventricular remodeling
摘要
Abstract
Objective To investigate the role and underlying mechanisms of exosomes(EXOs)enriched with miR-29b in inhibiting post-myocardial infarction(MI)ventricular remodeling.Methods miR-29b-enriched EXOs were engineered via in vitro transfection and administered to MI-induced mice through tail vein injection.The experiment was divided into four groups:normal control,MI model,EXO-treated,and miR-29b-enriched EXO-treated.Cardiac function,ventricular remodeling,and related molecular mechanisms were assessed using echocardiography,histopathological staining,and Western blot analysis.Results Compared to the MI model group,miR-29b-enriched EXO treatment significant improved post-MI cardiac function,in the miR-29b-enriched EXO group.miR-29b overexpression in cardiac tissue correlated with downregulated collagen I and collagen III expression.Conclusion Tail vein injection of miR-29b-enriched EXOs effectively suppresses ventricular remodeling post-MI by targeting myocardial fibrosis.This study highlights the potential of miRNA-engineered exosomes as a novel therapeutic strategy for cardiovascular diseases.关键词
急性心肌梗死/外泌体/miR-29b/心室重构/心肌纤维化Key words
Acute myocardial infarction/Exosome/miR-29b/Ventricular remodeling/Myocardial fibrosis引用本文复制引用
郑伟,王晓明,韩志伟,邹龙,范晨亮,孙宏达,员建平..富集miR-29b的外泌体在心肌梗死后抑制心室重构的影响[J].中国体外循环杂志,2025,23(3):258-262,268,6.基金项目
内蒙古自治区自然科学基金资助项目(2022LHMS08014) （2022LHMS08014）
内蒙古医科大学联合项目(YKD2021LH093) （YKD2021LH093）
内蒙古自治区2022年卫生健康科技计划项目(202201508) （202201508）
