中国体外循环杂志2025，Vol.23Issue(3)：263-268,6.DOI:10.13498/j.cnki.chin.j.ecc.2025.03.14
肠道菌群失调通过T细胞免疫和炎症加剧心梗的机制及益生菌干预效果
Mechanisms of gut microbiota dysbiosis in exacerbating myocardial infarction via T cell immunity and inflammation and the effects of probiotic intervention
摘要
Abstract
Objective To investigate the effects of intestinal flora disturbance in regulating T-cell immunity,cardiac inflammation and myocardial collagen deposition in mice with myocardial infarction(MI).Methods A mouse model was established and the mice were divided into four groups:Sham,MI,MI+antibiotic treatment(MI+ABX)and MI+Probiotics intervention.Cardiac function was detected by ultrasound,and the changes of intestinal flora in mice in each group were analyzed.The spleen and heart Treg cells,as well as IL-17,IL-23 and IFN-γ,as well as myocardial collagen fiber deposition were detected by ELISA.Results Compared with Sham group,there were significant changes in the proportion of intestinal flora in all groups.Echocardiography revealed impaired cardiac function in the MI and MI+ABX groups,whereas probiotic intervention partially preserved cardiac function in the MI+Probiotics group.ELISA demonstrated elevated Treg levels in the MI group and decreased in the MI+ABX group,and restoration of Treg populations following probiotic treatment.In addition,the expression of cardiac inflammatory markers and myocardial collagen deposition was up-regulated in both the MI and MI+ABX groups,while the increase of inflammatory markers and collagen deposition was reversed to some extent in the MI+Probiotics group.Conclusion The imbalance of intestinal flora may aggravate the pathological process of myocardial infarction by affecting T cell immunity,cardiac inflammation and myocardial collagen fiber deposition.Probiotic intervention can significantly improve intestinal flora imbalance,restore heart function,reduce inflammatory response and myocardial fibrosis.关键词
肠道菌群/心肌梗死/T细胞免疫/心脏炎症/胶原沉积/心室重构Key words
Intestinal flora/Myocardial infarction/T-cell immunity/Heart inflammation/Collagen deposition/Ventricular remodeling引用本文复制引用
王亚莉,郝少婷,刘庆华,李玉明,杨向红,夏祎,苑晓鹤..肠道菌群失调通过T细胞免疫和炎症加剧心梗的机制及益生菌干预效果[J].中国体外循环杂志,2025,23(3):263-268,6.基金项目
邯郸市科学技术研究与发展计划项目(23422083441) （23422083441）
