中国畜牧杂志2025，Vol.61Issue(6)：119-124,6.DOI:10.19556/j.0258-7033.20240611-05
镉对牛肠道屏障功能及肝脏的毒性损伤机制研究进展
Research Progress on the Injury Mechanism of Cadmium on Bovine Intestinal Barrier Function and Liver
摘要
Abstract
The homeostasis of intestinal structure and microbiota in cattle is crucial for normal nutrient metabolism and overall health.The liver plays a key role in maintaining this homeostasis,particularly in metabolizing and detoxifying natural and synthetic exogenous substances absorbed through the gastrointestinal tract.As large ruminants,cattle often ingest forages and feeds contaminated with heavy metal cadmium,posing a significant threat to their health.Currently,research has mainly focused on the harmful effects of cadmium on the intestines and livers of monogastric animals,with few systematic reports on the intestinal health and liver toxicity in cattle.This review systematically elucidates the mechanisms by which cadmium damages bovine intestinal health and how it is transported from the intestine to the liver,where it accumulates and induces hepatotoxicity.By providing a comprehensive analysis,this review aims to establish a theoretical foundation for mitigating the health risks posed by cadmium pollution in cattle,enhancing intestinal health,and advancing the understanding of liver toxicity and detoxification mechanisms in cattle.关键词
镉/肠道健康/肝脏毒性/牛Key words
Cadmium/Gut health/Hepatotoxicity/Cattle分类
农业科技引用本文复制引用
张凯凯,赵元峰,胡荣斌,冉江,王安娜..镉对牛肠道屏障功能及肝脏的毒性损伤机制研究进展[J].中国畜牧杂志,2025,61(6):119-124,6.基金项目
贵州省科技计划项目(黔科合基础-ZK[2022]一般226) （黔科合基础-ZK[2022]一般226）
贵州省科技计划项目(黔科合成果[2023]一般021) （黔科合成果[2023]一般021）
贵州省农业科学院青年基金项目(黔农科青年基金[2023]04号) （黔农科青年基金[2023]04号）
贵州省肉牛现代农业产业技术体系建设项目(GZRNCYJSTX-02) （GZRNCYJSTX-02）
