中国药物经济学2025，Vol.20Issue(5)：64-67,71,5.DOI:10.12010/j.issn.1673-5846.2025.05.012
司美格鲁肽联合二甲双胍治疗新诊断肥胖2型糖尿病患者的临床疗效
Effect of Semiglutide Combined with Metformin on Newly Diagnosed Type 2 Diabetes Mellitus Patients with Obese
黎达香 1龚俊 1熊间贵 1张琰1
作者信息
- 1. 广西科技大学第一附属医院内分泌科,广西 柳州 545002
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy of semaglutide combined with metformin in the treatment of newly diagnosed obese patients with type 2 diabetes mellitus(T2DM).Methods Sixty patients with T2DM who were admitted and newly diagnosed in the First Affiliated Hospital of Guangxi University of Science and Technology from January to June 2024 were selected and divided into the observation group(n=30)and the control group(n=30)according to the random number table method.The control group was orally treated with metformin,while the observation group was treated with semaglutide combined with metformin.The obesity indicators[weight,body mass index(BMI),waist circumference]and glucose metabolism indicators[fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPBG),glycated hemoglobin(HbA1c),lipid metabolism indicators[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]and adverse reactions of the two groups of patients were compared.Results After the treatment,the body weight,BMI and waist circumference of the observation group were lower than those of the control group(P＜0.05).After treatment,the levels of FPG,2hPBG and HbA1c in the observation group were lower than those in the control group(P＜0.05).After the treatment,TC,TG and LDL-C in the observation group were lower than those in the control group,and HDL-C was higher than that in the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Semaglutide combined with metformin is safe and effective in the treatment of newly diagnosed obese patients with type 2 diabetes mellitus(T2DM).It can significantly lower blood glucose,blood lipid and control body weight,and its effect is superior to that of metformin monotherapy.关键词
2型糖尿病/司美格鲁肽/肥胖/二甲双胍Key words
Type 2 diabetes mellitus/Semiglutide/Obese/Metformin分类
临床医学引用本文复制引用
黎达香,龚俊,熊间贵,张琰..司美格鲁肽联合二甲双胍治疗新诊断肥胖2型糖尿病患者的临床疗效[J].中国药物经济学,2025,20(5):64-67,71,5.
