中国药物经济学2025，Vol.20Issue(5)：76-79,4.DOI:10.12010/j.issn.1673-5846.2025.05.015
依达拉奉右莰醇通过调控TLR4/NF-κB信号通路保护脑缺血再灌注损伤对炎症因子改变的影响
Edaravone Dexcamphene Protects the Effect of Cerebral Ischemia-reperfusion Injury on the Changes of Inflammatory Factors by Regulating the TLR4/NF-κB Signaling Pathway
摘要
Abstract
Objective To explore the effect of edaravone dexcamphene on the changes of inflammatory factors in protecting cerebral ischemia-reperfusion injury by regulating the TLR4/NF-κB signaling pathway.Methods Hippocampal neuron cells were cultured and divided into the control group,the model group and the administration group.The control group was cultured with normal hippocampal neurons in the culture medium,The model group was cultured by adding ischemia-reperfusion injury hippocampal neurons to the culture medium.The administration group cultured hippocampal neurons with ischemia-reperfusion injury in the culture medium,and at the same time,1.25 µmol/L edaravone and dexcamphene were added to the interference group.The expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were detected by enzyme-linked immunosorbent assay(ELISA),and the expression levels of TLR4 and nuclear factor-κB(NF-κB)were detected by Western blotting.Results The expression levels of IL-6 and TNF-α in the model group were higher than those in the contro group,and the expression levels of IL-6 and TNF-α in the administration group were lower than those in the model group,the differences were statistically significant(P＜0.05).The expression levels of TLR4 and NΚ-κB in the model group were higher than those in the contro group,while the expression levels of TLR4 and NΚ-κB in the administration group were lower than those in the model group,the differences were statistically significant(P＜0.05).Conclusion Edaravone and dexcamphene can alleviate the inflammatory response after cerebral ischemia-reperfusion injury and reduce the levels of inflammatory factors by regulating the TLR4/NF-κB signaling pathway.关键词
依达拉奉右莰醇/脑缺血再灌注损伤/炎症反应/TLR4/NF-κB通路Key words
Edaravone right camphor/Cerebral ischemia-reperfusion injury/Inflammatory response/TLR4/NF-ΚB pathway分类
临床医学引用本文复制引用
赵海清,覃玉梅..依达拉奉右莰醇通过调控TLR4/NF-κB信号通路保护脑缺血再灌注损伤对炎症因子改变的影响[J].中国药物经济学,2025,20(5):76-79,4.基金项目
广西药学会医院药学科研项目(GXYXH1-202201) （GXYXH1-202201）
