摘要
Abstract
Objective To explore the effects of Sacubitril Valsartan Sodium on serum N-terminal pro-B-type natriuretic peptide(NT-proBNP)and inflammatory factors in elderly patients with coronary atherosclerotic heart disease after percutaneous coronary intervention(PCI).Methods Two hundred elderly patients with coronary atherosclerotic heart disease after PCI who were admitted to Liaoning Golden Autumn Hospital from September 2020 to September 2023 were selected and divided into the observation group and the control group according to different treatment methods,with 100 cases in each group.The control group was given conventional drug treatment,while the observation group was treated with Sacubitril Valsartan Sodium in addition to the control group.The cardiac function indicators[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)],serum NT-proBNP and the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]and the incidence of adverse cardiac events were compared between the two groups of patients.Results Before treatment,there was no statistically significant difference in LVEF,LVEDD and LVESD between the two groups(P＞0.05).After the treatment,LVEF increased in both groups,while LVEDD and LVESD decreased.Moreover,LVEF in the observation group was higher than that in the control group,and LVEDD and LVESD were lower than those in the control group.The differences were statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in the levels of serum NT-proBNP,TNF-α and CRP between the two groups(P＞0.05).After treatment,the levels of serum NT-proBNP,TNF-α and CRP in both groups decreased(P＜0.05),and the levels of serum NT-proBNP,TNF-α and CRP in the observation group were lower than those in the control group(P＜0.05).The incidence of adverse cardiac events in the observation group was lower than that in the control group(P＜0.05).Conclusion The application of Sacubitril Valsartan Sodium ahter PCI for elderly patients with coronary atherosclerotic heart disease has a significant improvement effect on the cardiac function of patients,and can effectively reduce the levels of NT-proBNP and inflammatory factors,and reduce the occurrence of adverse cardiac events.关键词
沙库巴曲缬沙坦钠/冠状动脉粥样硬化性心脏病/经皮冠状动脉介入治疗/N末端B型利钠肽前体/炎症因子Key words
Sacubitril Valsartan Sodium/Coronary atherosclerotic heart disease/Percutaneous coronary intervention/N-terminal pro-B-type natriuretic peptide/Inflammatory factors分类
临床医学
