中国脑血管病杂志2025，Vol.22Issue(5)：335-342,8.DOI:10.3969/j.issn.1672-5921.2025.05.007
斑块内新生血管在颈动脉粥样硬化中的作用研究进展
Advances research on the role of intraplaque neovascularization in carotid atherosclerosis
摘要
Abstract
Intraplaque neovascularization(IPN)is a critical feature of carotid atherosclerosis progression and plaque vulnerability.IPN may originate from the adventitial or the luminal side,and its structural defects may exacerbate inflammatory responses,leading to plaque destabilization.Metabolic disorders,inflammatory reactions,and oxidative stress collectively promote IPN formation.Lipid-lowering agents and anti-angiogenic therapies have demonstrated potential in stabilizing plaques,though their precision requires further enhancement.IPN grading correlates with stroke recurrence risks and offers guidance for clinical decision-making.This article aimed to review the pathological mechanisms,detection methods,risk factors,clinical significance of grading,and therapeutic strategies of IPN,thereby providing a scientific basis for the clinical assessment and management of carotid atherosclerosis.关键词
颈动脉粥样硬化/斑块内新生血管/病理机制/治疗策略/综述Key words
Carotid atherosclerosis/Intraplaque neovascularization/Pathological mechanisms/Therapeutic strategies/Review引用本文复制引用
李亭亭,刘晓璐,朱海英..斑块内新生血管在颈动脉粥样硬化中的作用研究进展[J].中国脑血管病杂志,2025,22(5):335-342,8.基金项目
济南市卫生健康委员会2023年科技计划项目(2023-2-75) （2023-2-75）
