中国医药科学2025，Vol.15Issue(10)：25-28,4.DOI:10.20116/j.issn2095-0616.2025.10.05
整合素调控牙周膜细胞迁移的研究进展
Research progress of integrin regulating periodontal ligament cell migration
摘要
Abstract
Periodontitis is a chronic inflammation,and its progress is a complicated process.Periodontal ligament(PDL)cells can migrate to the wound to regenerate periodontal fibers and adjacent hard tissues.Integrin belongs to the family of cell adhesion molecules(CAM)and acts as a cell surface receptor for specific ligands.Integrin binds to different extracellular matrix(ECM)proteins,including fibronectin(FN)and periostin(PN),which affect the migration of PDL cells.FN mainly binds to integrin α5β1 in PDL,and PN acts as the ligand of integrins αvβ3 and αvβ5.Integrin regulates the migration of PDL on collagen fibers,thus guiding specific cell groups into periodontal defects.In periodontitis,the expression and function of integrin are also regulated by cytokines,including transforming growth factor β and interleukin-1.This paper mainly discusses the research progress of integrins in regulating PDL cell migration,in order to provide better diagnosis and treatment ideas.关键词
整合素/牙周组织/牙周膜细胞/牙周再生/细胞外基质Key words
Integrin/Periodontal tissue/Periodontal ligament cells/Periodontal regeneration/Extracellular matrix分类
医药卫生引用本文复制引用
张琳琳,高玉光,高艳..整合素调控牙周膜细胞迁移的研究进展[J].中国医药科学,2025,15(10):25-28,4.基金项目
国家自然科学基金项目(81870738). （81870738）
