转化医学杂志2025，Vol.14Issue(4)：171-175,5.DOI:10.3639/j.issn.2095-3097.2025.04.033
伏诺拉生四联方案与雷贝拉唑四联方案对幽门螺杆菌感染患者肠道菌群及T淋巴细胞亚群、胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ的影响
Comparison of Effects of Vonoprazan and Rabeprazole Quadruple Regimen on Intestinal Flora and Pepsin in Hp Infected Patients
摘要
Abstract
Objective To observe and compare the effects of Vonoprazan quadruple regimen and rabeprazole quadruple therapy on intestinal flora disorders,T-cell immunity,PG Ⅰ,PG Ⅱ in patients with Hp infection.Methods A total of 92 pa-tients with Hp infection admitted to Linfen People's Hospital from January 2023 to January 2024 were selected as study subjects and randomly divided into the control group and the study group,with 46 cases in each group.The control group was treated with Rabeprazole and the study group was treated with Vonoprazan.The eradication rate of Hp in both groups and the levels of serum inflammatory factors,intestinal flora,intestinal flora disorder grade,T-cell immunity,PG Ⅰ,PG Ⅱ,PG Ⅰ/Ⅱ and G-17 before and after treatment were compared.Results There was no significant difference in Hp eradication rate between the two groups(P＞0.05).There were no significant differences in intestinal flora,intestinal flora imbalance grade,T cell immunity,in-flammatory factors,PG Ⅰ,PG Ⅱ,PG Ⅰ/Ⅱ or G-17 between the two groups before treatment(P＞0.05).After treatment,Lac-tobacillus,Bacteroides,Bifidobacterium,CD3+,CD4+,CD4+/CD8+,and PG Ⅰ/Ⅱ were increased in both groups,with the study group showing higher values than the control group.Coccibacterium,Escherichia coli,intestinal flora disorder grade,PCT,CRP,TNF-α,TGF-β1,CD8+,PG Ⅰ,PG Ⅱ,and G-17 decreased,with the study group showing lower than the control group(P＜0.05).Conclusion Both Vonoprazan and Rabeprazole can effectively clear Hp infection,but Vonoprazan can further inhibit the ex-pression of inflammatory factors and inflammatory damage in patients,regulate the intestinal flora of patients,reduce intestinal flora disorder grading,and modulate T-cell immunity as well as the levels of PG Ⅰ,PG Ⅱ,PG Ⅰ/Ⅱ and G-17.关键词
幽门螺杆菌感染/伏诺拉生/雷贝拉唑/胃肠道微生物组/T淋巴细胞亚群/胃蛋白酶原Ⅰ/胃蛋白酶原ⅡKey words
Hp infection/Vonoprazan/Rabeprazole/Intestinal flora/T-cell immunity/PG Ⅰ/PG Ⅱ分类
临床医学引用本文复制引用
刘小涛,张玲玥,张佳佳..伏诺拉生四联方案与雷贝拉唑四联方案对幽门螺杆菌感染患者肠道菌群及T淋巴细胞亚群、胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ的影响[J].转化医学杂志,2025,14(4):171-175,5.基金项目
山西省教育厅高等学校科技创新计划各类项目(2020L0225) （2020L0225）
