中国医药科学2025，Vol.15Issue(10)：109-112,130,5.DOI:10.20116/j.issn2095-0616.2025.10.24
老年非瓣膜性心房颤动住院患者的抗凝治疗状况及对患者认知功能的影响
Anti-coagulation therapy status and its impact on cognitive function in hospitalized elderly patients with non valvular atrial fibrillation
摘要
Abstract
Objective To analyze the anti-coagulation therapy status and its impact on cognitive function in hospitalized elderly patients with non valvular atrial fibrillation.Methods The general data of a total of 210 elderly patients with non valvular atrial fibrillation admitted to the Fourth Hospital of Changsha from August 2022 to August 2023 were retrospectively analyzed.The patients were divided into the non anti-coagulation group(n=92)and the anti-coagulation group(n=118)based on whether they received anti-coagulation therapy.Multiple logistic regression was used to analyze the impacting factors of anti-coagulant therapy in elderly hospitalized patients with non valvular atrial fibrillation.Six months after discharge,the incidences of stroke and cognitive function impairment between two groups of patients were compared.Results The proportion of patients aged≥75 years,history of stroke,history of hemorrhage,heart failure,coronary heart disease,hypertension,fasting blood glucose,and low-density lipoprotein cholesterol levels in the non anti-coagulant group were higher than those in the anti-coagulant group,with statistically significant differences(P<0.05).The results of multiple logistic regression analysis showed that age≥75 years,history of hemorrhage,and heart failure were independent risk factors impacting anti-coagulant therapy in elderly hospitalized patients with non valvular atrial fibrillation,while stroke history was a protective factor(P<0.05).The incidence of stroke and cognitive function impairment in the anti-coagulation group was lower than that in the non anti-coagulation group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of hemorrhage between the two groups of patients(P>0.05).Conclusion The anti-coagulation treatment rate for elderly hospitalized patients with non valvular atrial fibrillation is not high,with age≥75 years,history of hemorrhage,history of stroke,and heart failure being the main factors impacting anti-coagulation treatment for elderly hospitalized patients with non valvular atrial fibrillation;Anti-coagulation therapy has a certain preventive effect on cognitive function impairment in elderly patients with non valvular atrial fibrillation,and can reduce the incidence of cognitive function impairment.关键词
非瓣膜性心房颤动/老年住院患者/抗凝治疗/影响因素/认知功能Key words
Non valvular atrial fibrillation/Elderly hospitalized patients/Anti-coagulant therapy/Impacting factors/Cognitive function分类
医药卫生引用本文复制引用
沙莎,杨晓芳..老年非瓣膜性心房颤动住院患者的抗凝治疗状况及对患者认知功能的影响[J].中国医药科学,2025,15(10):109-112,130,5.基金项目
湖南省卫生健康委科研立项课题(202216003050). （202216003050）
