中国医药科学2025，Vol.15Issue(10)：140-143,161,5.DOI:10.20116/j.issn2095-0616.2025.10.31
经鼻高流量湿化氧疗在慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭患者中的临床应用
Clinical application of high-flow nasal cannula oxygen therapy in patients with acute exacerbation of chronic obstructive pulmonary disease complicated by type Ⅱ respiratory failure
摘要
Abstract
Objective To investigate the effect of high-flow nasal cannula oxygen therapy(HFNC)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated by type Ⅱ respiratory failure.Methods 120 patients(RICU)AECOPD complicated with typeⅡ respiratory failure in respiratory intensive care unit(RICU)of the First People's Hospital of Chenzhou City from June 2022 to December 2023 were selected as the research objects.Divided into noninvasive positive pressure ventilation according to random number table method.(NIPPV)group(n=60)and HFNC group(n=60)were treated with non-NIPPV and HFNC respectively,and the respiratory and circulatory indexes and blood gas of the two groups were compared.Indicators,incidence of adverse reactions,clinical outcome indicators.Results The respiratory frequency(RR),heart rate(HR),mean arterial pressure(MAP)and incidence of adverse reactions in HFNC group were lower than those in NIPPV group,with statistically significant differences(P<0.05).The oxygen partical pressure in HFNC group was higher than that in NIPPV group 24 and 48 hours after treatment,with statistically significant differences(P<0.05).Compared with NIPPV group,the hospitalization time in HFNC group was shorter,with statistically significant differences(P<0.05).There was no significant difference in blood pH,partial pressure of carbon dioxide(PaCO2),lactic acid(Lac),incidence of pneumothorax,incidence of tracheal intubation and mortality between the two groups(P>0.05).Conclusion The application of HFNC in the clinical treatment of patients with AECOPD complicated with type Ⅱ respiratory failure can not only improve the hypoxia state,but also reduce the occurrence of adverse reactions,so it is recommended to be popularized in clinic.关键词
经鼻高流量湿化氧疗/无创正压通气/慢性阻塞性肺疾病急性加重期/Ⅱ型呼吸衰竭/呼吸/不良反应Key words
High-flow nasal cannula oxygen therapy/Non-invasive positive pressure ventilation/Acute exacerbation of chronic obstructive pulmonary disease/Type Ⅱ respiratory failure/Respiration/Adverse reactions分类
临床医学引用本文复制引用
李茉莉,刘俊永,罗庆凯,伍峻仪,熊艺为..经鼻高流量湿化氧疗在慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭患者中的临床应用[J].中国医药科学,2025,15(10):140-143,161,5.基金项目
湖南省郴州市技术创新引导项目(1cy12021061). （1cy12021061）
