浙江中医药大学学报2025，Vol.49Issue(5)：617-621,5.DOI:10.16466/j.issn1005-5509.2025.05.014
基于肠道关键菌探究中医药治疗肺癌的潜在靶点
Exploring the Potential Targets of Traditional Chinese Medicine for Lung Cancer Treatment Based on Intestinal Flora
摘要
Abstract
[Objective]To explore the potential therapeutic targets of traditional Chinese medicine(TCM)in the treatment of lung cancer,based on the differences in gut microbiota,for providing new ideas for the TCM diagnosis and treatment of lung cancer.[Methods]Beginning with the TCM theories"Interior-exterior relationship between the lung and the large intestine"and"Simultaneous treatment of lung and intestine",integrating clinical research and empirical evidence,this study aims to clarify the feasibility of treating lung cancer by targeting gut microbiota and to summarize key gut microbiota targets in TCM for lung cancer treatment.[Results]Ancient Chinese medical literature and modern medical research provide a reliable theoretical basis for treating lung cancer based on intestinal microbiota.Empirical clinical prescriptions can regulate the composition and metabolism of gut microbiota.Some of the Chinese medicines in these prescriptions can specifically increase the abundance of key bacteria such as Lactobacillus,Faecalibacterium,and Bifidobacterium,thereby playing a positive role in the treatment of lung cancer.[Conclusion]There is a potential correlation between key gut microbiota in lung cancer patients and Chinese medicine,and regulating gut microbiota may be a target for TCM treatment of lung cancer.In depth exploration of the specific correlation between Chinese medicine and key bacteria,targeting the regulation of gut microbiota to formulate prescriptions,may become a new approach for TCM treatment of lung cancer.关键词
肺癌/肠道菌群/中医/肺肠轴/肺肠同治/文献研究/临床研究/非小细胞肺癌Key words
lung cancer/intestinal flora/traditional Chinese medicine/lung and intestinal axis/simultaneous treatment of lung and intestine/literature research/clinical research/NSCLC分类
医药卫生引用本文复制引用
吕心怡,陈思敏,王雅楠,贺佳慧,于清茜,陈佳易,侯春英,宋月晗..基于肠道关键菌探究中医药治疗肺癌的潜在靶点[J].浙江中医药大学学报,2025,49(5):617-621,5.基金项目
国家自然科学基金青年项目(81903935) Youth Program of National Natural Science Foundation Project(81903935) （81903935）
