中国医药科学2025，Vol.15Issue(9)：60-64,5.DOI:10.20116/j.issn2095-0616.2025.09.14
气相色谱法测定乙酰半胱氨酸注射液中硫化氢含量
Determination of hydrogen sulfide content in acetylcysteine injection by gas chromatography
赵长凤 1黄道明 2白波波 3姚丽珍 3卢雅玉 3王翰斌3
作者信息
- 1. 山西阳和医药技术有限公司,山西 大同 037000
- 2. 文韬创新药物研究(北京)股份有限公司,北京 100000
- 3. 山西普恒制药有限公司,山西 大同 037000
- 折叠
摘要
Abstract
Objective To determine the content of hydrogen sulfide in acetylcysteine injection in order to control product quality.Methods Gas chromatography method with a flame photometric detector and headspace sampling technique to detect hydrogen sulfide content in acetylcysteine injection through a controlled variable approach.Results Hydrogen sulfide showed a linear relationship within the concentration range of 1.25 to 4.00 µg/ml,with the minimum detectable concentration of 0.025 µg/ml.Conclusion The detection results obtained using this method are stable and reliable,allowing for the accurate and rapid determination of hydrogen sulfide in acetylcysteine injection.关键词
乙酰半胱氨酸注射液/气相色谱法/FPD检测器/硫化氢Key words
Acetylcysteine injection/Gas chromatography/Flame photometric detector/Hydrogen sulfide分类
能源科技引用本文复制引用
赵长凤,黄道明,白波波,姚丽珍,卢雅玉,王翰斌..气相色谱法测定乙酰半胱氨酸注射液中硫化氢含量[J].中国医药科学,2025,15(9):60-64,5.
