中国医药科学2025，Vol.15Issue(9)：81-85,5.DOI:10.20116/j.issn2095-0616.2025.09.19
改良经内镜逆行胰胆管造影术在高位胆道梗阻性黄疸中的病理活检及治疗效果研究
Pathological biopsy and therapeutic efficacy of modified endoscopic retrograde cholangio pancreatography in high biliary obstructive jaundice
摘要
Abstract
Objective To investigate the pathological biopsy and therapeutic efficacy of modified endoscopic retrograde cholangio pancreatography(ERCP)in patients with high biliary obstructive jaundice.Methods A total of 100 patients with high biliary obstructive jaundice who received treatment in the Department of Gastroenterology of the Second Affiliated Hospital of Mudanjiang Medical College from January 2022 to January 2024 were selected as study subjects.They were divided into the ERCP group(n=50)and the PTCD group(n=50)according to the pathway.The ERCP group was treated with modified ERCP pathway,while the PTCD group was treated with percutaneous transhepatic cholangial drainage(PTCD)pathway.The success rates of catheterization,successful sampling rates,postoperative pathological consistency rates,incidence of adverse reactions(ADRs),and clinical treatment outcomes between two groups were compared.Results There were no statistically significant differences in the success rate of catheterization,successful sampling rate,and postoperative pathological consistency rates between the two groups(P>0.05).The incidence of ADRs in the ERCP group was 8.00%,lower than 26.00%in the PTCD group,with statistically significant difference(P<0.05).At 3 and 7 days after surgery,the levels of total bilirubin,direct bilirubin,alanine amino-transferase(ALT),and aspartate transferase(AST)in both groups were all significantly lower than those before surgery,while the levels at 7 days after surgery were significantly lower than those at 3 days after surgery,with statistically significant differences(P<0.05).At 3 days after surgery,the direct bilirubin level in the ERCP group was lower than that in the PTCD group,with statistically significant difference(P<0.05).At 7 days after surgery,the levels of ALT and AST in the ERCP group were lower than those in the PTCD group,with statistically significant differences(P<0.05).Conclusion The improved ERCP pathway for biliary biopsy in patients with high obstructive jaundice has a success rate comparable to PTCD,but with advantages such as minimal trauma and fewer ADRs.关键词
ERCP/PTCD/胆道活检/高位胆道梗阻性黄疸Key words
ERCP/PTCD/Biliary biopsy/Obstructive jaundice of the high biliary tract分类
医药卫生引用本文复制引用
朱洪春,张红梅,陶英歌..改良经内镜逆行胰胆管造影术在高位胆道梗阻性黄疸中的病理活检及治疗效果研究[J].中国医药科学,2025,15(9):81-85,5.基金项目
黑龙江省省属高等学校基本科研业务费科研项目(2022-KYYWF-0668). （2022-KYYWF-0668）
