中国医药科学2025，Vol.15Issue(9)：99-103,159,6.DOI:10.20116/j.issn2095-0616.2025.09.23
加味丹玄口康治疗口腔黏膜下纤维化的临床观察
Clinical observation of Jiawei Danxuan Koukang in the treatment of oral submucous fibrosis
摘要
Abstract
Objective To study the clinical efficacy mechanism of Jiawei Danxuan Koukang(JWDXKK)in the treatment of oral submucous fibrosis(OSF).Methods A total of 60 OSF patients who visited the clinic of the Department of Stomatology of the No.1 Affiliated Hospital of Hunan Traditional Chinese Medicine University from February 2023 to June 2024 were collected,and the study subjects were divided into two groups of 30 patients each by using the random number table method.The treatment group was treated with JWDXKK Traditional Chinese Medicine Compound,and the control group was treated with Compound Danshen Dripping Pill combined with Vitamin E soft capsules.After two months of treatment,the clinical efficacy of the two groups and the effects of the two therapeutic drugs on blood rheology and peripheral blood T lymphocyte subsets were observed.Results The clinical symptom score of the treatment group was smaller than the clinical symptom score of the control group,and the difference was statistically significant(P<0.05).The indexes in the blood rheology of the treatment group were smaller than the indexes in the blood rheology of the control group,and the difference was statistically significant(P<0.05).The peripheral blood T lymphocyte subpopulation of the treatment group was smaller than the peripheral blood T lymphocyte subpopulation of the control group in terms of CD4+,CD4+/CD8+,and the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of JWDXKK in the treatment of OSF is remarkable,which can effectively improve microcirculation,regulate local immunity,inhibit collagen synthesis.关键词
加味丹玄口康/口腔黏膜下纤维化/血液流变学/外周血T淋巴细胞亚群Key words
Jiawei Danxuan Koukang/Oral submucous fibrosis/Hemorheology/Peripheral blood T lymphocyte subsets分类
医药卫生引用本文复制引用
刘玥,曾倩琪,叶瑶,谭劲..加味丹玄口康治疗口腔黏膜下纤维化的临床观察[J].中国医药科学,2025,15(9):99-103,159,6.基金项目
国家自然科学基金面上项目(82374530). （82374530）
