中国中医药图书情报杂志2025，Vol.49Issue(4)：76-82,7.DOI:10.3969/j.issn.2095-5707.202403095
基于网络药理学及分子对接探究通脉降糖胶囊治疗糖尿病周围神经病变作用机制
Exploration on the Mechanism of Tongluo Jiangtang Capsules in Treating Diabetic Peripheral Neuropathy with Based on Network Pharmacology and Molecular Docking
摘要
Abstract
Objective To explore the mechanism of Tongluo Jiangtang Capsules in treating diabetes peripheral neuropathy(DPN)through network pharmacology and molecular docking.Methods Targets related to DPN were retrieved from GeneCards,DisGeNET,OMIM databases,and TCMSP and HERB databases were used to obtain the active components and action targets in Tongluo Jiangtang Capsules.The intersection targets of disease and drug targets were obtained using the Venny 2.1.0.STRING database was used to construct protein-protein interaction network,and then GO and KEGG enrichment analysis of intersection targets was performed using DAVID database.The Chinese materia medica-active components-intersection targets network diagram was drawn in Cytoscape 3.8.0 software.The core targets and core active components were screened in descending order of degree value.Then the key targets and core active components were imported into AutoDock 1.5.7 software for molecular docking verification.Results A total of 2 043 disease targets with DPN were obtained,209 active components and 466 action targets were screened,and 194 intersection targets were identified.The top 3 targets were TNF,AKT1 and IL6,mainly involved in the regulation of PI3K-Akt,AGE-RAGE,MAPK and other pathways.The molecular docking results showed that TNF bound well to luteolin,quercetin,kaempferol,and crocetin,IL6 bound well with quercetin,luteolin and kaempferol.Conclusion Tongluo Jiangtang Capsules can treat DPN by targeting core targets such as TNF,AKT1 and IL6 and activating multiple signaling pathways including PI3K-Akt,AGE-RAGE and MAPK.关键词
通脉降糖胶囊/糖尿病周围神经病变/网络药理学/分子对接Key words
Tongluo Jiangtang Capsules/diabetic peripheral neuropathy/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
李泽锋,黄文锋..基于网络药理学及分子对接探究通脉降糖胶囊治疗糖尿病周围神经病变作用机制[J].中国中医药图书情报杂志,2025,49(4):76-82,7.基金项目
湛江市科技发展专项资金竞争性分配项目(2022A01065) （2022A01065）
