针灸推拿医学（英文版）2025，Vol.23Issue(3)：210-217,8.DOI:10.1007/s11726-025-1503-3
针刺对溃疡性结肠炎大鼠肠道菌群及炎症因子IL-6的影响
Effects of acupuncture on intestinal flora and inflammatory factor IL-6 in rats with ulcerative colitis
摘要
Abstract
Objective:To observe the effects of acupuncture on intestinal flora and inflammatory factor interleukin(IL)-6 in ulcerative colitis(UC)model rats and to explore the related mechanism of acupuncture in treating UC. Methods:Thirty-two Sprague-Dawley rats were randomly divided into a normal control(NC)group,a model(MO)group,a mesalazine(ME)group,and an acupuncture(AC)group,with 8 rats in each group.Rats,except those in the NC group,were given a 2.5%sodium dextran sulfate solution to establish UC models.After successful modeling,rats in the ME group were treated with mesalazine by gavage twice a day for 7 continuous days;rats in the AC group received acupuncture at bilateral Tianshu(ST25)and Zusanli(ST36)with needles retained for 20 min each time,once a day for 7 consecutive days.After intervention,changes in the intestinal flora diversity,colon tissue damage degree,and inflammatory factor expression in each group of rats were evaluated. Results:The body mass increased slowly in the MO group compared to the NC group.After intervention,the body mass increased more significantly,colon injuries recovered,and intestinal flora diversity improved in the ME and AC groups compared to the MO group(P<0.05).The IL-6 expression level was higher in the MO group compared to the NC group(P<0.05).The IL-6 expression level decreased in the AC group compared to the MO group(P<0.05). Conclusion:Acupuncture at Tianshu(ST25)and Zusanli(ST36)improves body mass loss and colon injuries,regulates intestinal flora diversity,and reduces the expression of inflammatory factor IL-6 in the colon tissue of UC rats,therefore alleviating the disease severity of UC.关键词
针刺疗法/穴,天枢/穴,足三里/结肠炎,溃疡性/炎症性肠病/胃肠道微生物群/白介素-6/大鼠Key words
Acupuncture Therapy/Point,Tianshu(ST25)/Point,Zusanli(ST36)/Colitis,Ulcerative/Inflammatory Bowel Disease/Gastrointestinal Microbiome/Interleukin-6/Rats分类
医药卫生引用本文复制引用
季蓉,朱小娟,郭海莲,周元培,陈栎遥,曹灿灿,黄丽强..针刺对溃疡性结肠炎大鼠肠道菌群及炎症因子IL-6的影响[J].针灸推拿医学（英文版）,2025,23(3):210-217,8.基金项目
This work was supported by the Youth Project of National Natural Science Foundation of China(国家自然科学基金青年项目,No.82004451) （国家自然科学基金青年项目,No.82004451）
Medical and Health Science and Technology Innovation Guiding Project of Zhangjiagang(张家港市医疗卫生科技创新指导性项目,No.ZKYL2260) （张家港市医疗卫生科技创新指导性项目,No.ZKYL2260）
Suzhou Science and Technology Development Program(苏州科技发展计划项目,No.SKYD2022045,No.SKY2022071) （苏州科技发展计划项目,No.SKYD2022045,No.SKY2022071）
Science and Technology Project of Zhangjiagang Bureau of Science and Technology(张家港市科技计划项目,No.ZKS2133) （张家港市科技计划项目,No.ZKS2133）
Youth Project of Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine(张家港市中医医院青年项目,No.ZZYQ2107). （张家港市中医医院青年项目,No.ZZYQ2107）
