针灸推拿医学（英文版）2025，Vol.23Issue(3)：239-249,11.DOI:10.1007/s11726-025-1506-0
围手术期电针促进结直肠癌根治术后早期胃肠功能康复:一项预试验研究方案
Perioperative electroacupuncture for early gastrointestinal function recovery after colorectal cancer surgery:a pilot study protocol
摘要
Abstract
Objective:A preliminary trial is conducted to explore whether perioperative(preoperative,intraoperative,and postoperative)electroacupuncture is more effective than postoperative electroacupuncture in improving gastrointestinal function for colorectal cancer patients. Methods and analysis:The study proposes a randomized,parallel-controlled,single-center trial involving 30 colorectal cancer patients aged 18-79 requiring elective surgery.Participants are randomly assigned to two groups,with equal allocation,where one group receives perioperative electroacupuncture,and the other group receives postoperative electroacupuncture.The treatment duration spans from preoperative to postoperative 72 h,with a subsequent 28-day follow-up period.The primary outcome is the time of first postoperative defecation.The secondary outcomes include the recovery time of postoperative bowel sounds,time of the first flatus,dietary recovery,postoperative gastrointestinal dysfunction frequency,quality of life scale,postoperative pain degree,time of the first ambulation,length of hospital stay,gastrointestinal hormone indicators,and adverse events.The coagulation function test,liver and renal function,and stool and blood routine serve as security biomarkers.The statistical analysis includes the t-test,rank-sum test,Chi-square test,and analysis of variance.A two-sided significance level is set at 5%. Discussion:This study aims to evaluate the feasibility and preliminary effectiveness of perioperative electroacupuncture for gastrointestinal function recovery following colorectal cancer surgery.The study's strengths include its randomized design,well-defined intervention periods,and multi-dimensional outcome assessment.Nevertheless,limitations,such as the small sample size and single-center setting,may affect external validity.The findings will guide protocol refinement and sample size estimation for future large-scale multi-center randomized controlled trials.关键词
针刺疗法/电针/围手术期/结直肠肿瘤/术后并发症/胃肠功能紊乱Key words
Acupuncture Therapy/Electroacupuncture/Perioperative Period/Colorectal Neoplasms/Postoperative Complications/Gastrointestinal Dysfunction分类
医药卫生引用本文复制引用
吴皎皎,周嘉,魏绪强,冯寿全,顾群浩,李璟,叶子,冯晨晨,裴丽娟,彭艳斌..围手术期电针促进结直肠癌根治术后早期胃肠功能康复:一项预试验研究方案[J].针灸推拿医学（英文版）,2025,23(3):239-249,11.基金项目
This study was supported by the Project of National Natural Science Foundation of China(国家自然科学基金,No.82074163) （国家自然科学基金,No.82074163）
Key Disciplines Construction Project of High-level Traditional Chinese Medicine(Acupuncture)by the State Administration of Traditional Chinese Medicine[国家中医药管理局高水平中医药重点学科(针灸学)建设项目,No.ZYYZDXK-2023068] （Acupuncture）
Acupuncture Clinical Research Center of Shanghai(上海市针灸临床医学研究中心,No.20MC1920500) （上海市针灸临床医学研究中心,No.20MC1920500）
Shanghai Science and Technology Commission Project(上海市科委重大临床研究项目,No.21Y31920100). （上海市科委重大临床研究项目,No.21Y31920100）
