转化医学杂志2025，Vol.14Issue(4)：82-86,5.DOI:10.3639/j.issn.2095-3097.2025.04.016
龈沟液SICAM-1、RANKL在预测种植体周炎患者预后中的临床价值
Clinical Value of sICAM-1 and RANKL in Gingival Crevicular Fluid in Predicting the Prognosis of Patients with Peri-Implantitis
摘要
Abstract
Objective To investigate the clinical value of gingival crevicular fluid human soluble intercellular adhesion molecule-1(sICAM-1)and nuclear factor-κB receptor activator ligand(RANKL)in predicting the prognosis of peri-implan-titis(PI)patients.Methods Eighty-eight PI patients treated at our hospital from January 2020 to June 2024 were enrolled.Gingival crevicular fluid specimens were collected,and sICAM-1 and RANKL levels were measured via enzyme-linked immu-nosorbent assay(ELISA).Based on 6-month follow-up outcomes,PI patients were divided into the good prognosis group(n=63)and the poor prognosis group(n=25).Receiver operating characteristic(ROC)curves and area under the curve(AUC)were used to evaluate predictive performance,and multivariate logistic stepwise regression identified risk factors for the prognosis.Results The poor prognosis group had higher sICAM-1 and RANKL levels than the good prognosis group((P＜0.05).ROC analysis re-vealed AUCs(95％CI)of 0.839(0.794-0.889)for sICAM-1,0.751(0.706-0.801)for RANKL,and 0.924(0.874-0.974)for their combination.The poor prognosis group had higher proportions of smokers,implants＞13 mm,and history of periodontitis((P＜0.05).Multivariate analysis identified periodontitis history(OR=2.208,95％CI:1.052-4.631),gingival crevicular fluid sI-CAM-1(OR=3.442,95％CI:1.908-6.209),and RANKL(OR=4.437,95％CI:2.132-9.235)as independent risk factors(P＜0.05).Conclusion The levels of sICAM-1 and RANKL are significantly elevated in PI patients with poor prognosis.The combined detection of the two can help predict the prognosis of PI patients.关键词
种植体周炎/可溶性细胞间黏附分子/核因子-κB受体活化因子配体/预后Key words
Peri-implantitis/Soluble intercellular adhesion molecule/Receptor activator of nuclear factor-κB ligand/Prognosis分类
医药卫生引用本文复制引用
慕童,江燕军,张勇,李昀生,方晓会,杨淑丽,乔雪峰..龈沟液SICAM-1、RANKL在预测种植体周炎患者预后中的临床价值[J].转化医学杂志,2025,14(4):82-86,5.基金项目
应急管理部重点科技计划项目(2024EMST141407) （2024EMST141407）
