转化医学杂志2025，Vol.14Issue(4)：87-91,5.DOI:10.3639/j.issn.2095-3097.2025.04.017
总胆固醇/高密度脂蛋白胆固醇比值对老年慢性心力衰竭患者主要不良心血管事件的预测价值
The Predictive Value of Total Cholesterol/High-Density Lipoprotein Cholesterol Ratio for Major Adverse Cardiovascular Events in Elderly Patients with Chronic Heart Failure
摘要
Abstract
Objective To explore the predictive value of the total cholesterol(TC)/high-density lipoprotein cholesterol(HDL-C)ratio for major adverse cardiovascular events(MACE)in elderly patients with chronic heart failure(CHF).Meth-ods A total of 106 elderly CHF patients from January 2022 to January 2024 were enrolled as the research subjects and followed up for one year.They were divided into the non-MACE group(n=75)and the MACE group(n=31)based on the occurrence of MACE during follow-up.Demographic and clinical data,TC,and HDL-C levels were collected,and the TC/HDL-C ratio was cal-culated.The predictive value of the TC/HDL-C ratio for MACE was analyzed using ROC curve analysis;risk factors for MACE were explored via multivariate logistic stepwise regression analysis.Results TC levels and TC/HDL-C ratio in the MACE group were significantly higher than those in the non-MACE group,while HDL-C levels were lower(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of the TC/HDL-C ratio for predicting MACE was 0.917(95％CI:0.867-0.956),which was higher than those of TC alone(AUC=0.728)and HDL-C alone(AUC=0.851)(Z=9.137 and 11.759,respectively;P＜0.001).The age,proportion of NYNA classs Ⅳ heart failure,and BNP levels in the MACE group were higher than those in the non-MACE group,while LVEF was lower(P＜0.05).Age,NYHA class,and TC/HDL-C ratio were independent risk factors for MACE,where-as LVEF was an independent protective factor(P＜0.05).Conclusion An elevated TC/HDL-C ratio is strongly associated with MACE in elderly CHF patients and demonstrates strong predictive performance for MACE in this population.关键词
总胆固醇/高密度脂蛋白胆固醇比值/慢性心力衰竭/老年/主要不良心血管事件/预测价值Key words
Total cholesterol/high-density lipoprotein cholesterol ratio/Chronic heart failure/Elderly/Major Adverse cardiovascular events/Predictive value分类
医药卫生引用本文复制引用
周希玲,赵燕,黄娟,吴奇,宾晓红,彭家慧..总胆固醇/高密度脂蛋白胆固醇比值对老年慢性心力衰竭患者主要不良心血管事件的预测价值[J].转化医学杂志,2025,14(4):87-91,5.基金项目
四川省科技厅重点研发项目(24ZDYF0624) （24ZDYF0624）
