神经药理学报2025，Vol.15Issue(1)：19-24,6.DOI:10.3969/j.issn.2095-1396.2025.01.004
舍曲林联合CCBT治疗精神分裂症后抑郁对患者临床症状及自理能力的影响
Effects of Sertraline Combined with CCBT on Clinical Symptoms and Self-Care Abilities in Patients with Post-Schizophrenia Depression
摘要
Abstract
Objective:The current investigation aims to assess the effectiveness and practical worth of a combined treatment approach that incorporates sertraline and computer-assisted cognitive behavioral therapy(CCBT)for individuals experiencing depression subsequent to schizophrenia.Methods:The research methodology involved the selection of 68 participants who were diagnosed with post-schizophrenia depression and were receiving care at our institution between April 2023 and May 2024.These individuals were allocated into two distinct cohorts—the control group,consisting of 34 individuals,and the experimental group,also comprising 34 individuals—through the application of a random number generator.Both groups received antipsychotic medication plus sertraline,while the observation group additionally received CCBT.Clinical symptoms,cognitive function,self-care abilities,quality of life improvement,and adverse reaction rates were observed and compared between the two groups at specific time points.Results:At the 4th,8th,and 12th weeks of treatment,the CDSS scores in the observation group were significantly higher than those in the control group,and the overall effective clinical treatment rate was also higher in the observation group(P<0.05).Comparing MCCB and ADL scores at the 4th,8th,and 12th weeks,the observation group scored higher than the control group(P<0.05).Post-treatment comparisons of SF-36 scores showed the observation group to be superior(P<0.05).The overall incidence of adverse reactions was lower in the observation group than in the control group(P<0.05).Conclusion:In patients with post-schizophrenia depression,the combination of sertraline and CCBT can effectively improve symptom alleviation and overall treatment efficacy,enhance cognitive function and self-care abilities,and contribute to the betterment of patients'quality of life.关键词
精神分裂症/抑郁/舍曲林/计算机化认知行为疗法/自理能力Key words
schizophrenia/depression/sertraline/computerized cognitive behavioral therapy/self-care abilities分类
药学引用本文复制引用
李晓丹,陈明,郑樱,王志坚,黄仁春..舍曲林联合CCBT治疗精神分裂症后抑郁对患者临床症状及自理能力的影响[J].神经药理学报,2025,15(1):19-24,6.基金项目
福州市科技计划项目(No.2023-S-028) （No.2023-S-028）
