神经药理学报2025，Vol.15Issue(1)：33-42,10.DOI:10.3969/j.issn.2095-1396.2025.01.006
神经炎症的分子基础与疾病进展研究
Research on the Molecular Basis of Neuroinf lammation and Disease Progression
摘要
Abstract
Inflammation is an innate defense response by which the body responds to external stimuli,maintaining internal homeostasis and protecting the central nervous system.However,excessive neuroinflammatory responses can induce neuronal degeneration and promote the development of neurological diseases.Numerous studies demonstrate that glial cells are critical in neuroinflammation through cellular phenotypic differentiation,inflammatory activation,cytokine release,and immune system regulation.This review examines the role of glial cells in neuroinflammation,analyzing inflammatory signaling pathways,key markers,and their relationships with central nervous system diseases,providing insights for potential therapeutic interventions targeting neuroinflammatory processes.关键词
神经炎症/小胶质细胞/星形胶质细胞/神经系统疾病Key words
neuroinflammation/microglia/astrocytes/nervous system disorders分类
药学引用本文复制引用
李亚慧,张瑜玉,张炜,孔德志..神经炎症的分子基础与疾病进展研究[J].神经药理学报,2025,15(1):33-42,10.基金项目
国家自然科学基金面上项目(No.82174004,No.82474103) （No.82174004,No.82474103）
