转化医学杂志2025，Vol.14Issue(4)：119-124,6.DOI:10.3639/j.issn.2095-3097.2025.04.023
富血小板纤维蛋白对正畸拔牙术后疼痛、牙周组织变化及牙齿移动的影响
Influence of PRF on Pain,Periodontal Tissue Changes and Tooth Movement after Orthodontic Extraction
摘要
Abstract
Objective To investigate the influence of platelet-rich fibrin(PRF)on pain,periodontal tissue changes and tooth movement after orthodontic tooth extraction.Methods From June 2023 to September 2024,120 malocclusion patients undergoing orthodontic extraction at Harrison International Peace Hospital were randomized into control(n=60)and observation(n=60)groups.Post-extraction,control sockets were cleaned and filled with natural clots,while observation sockets received PRF gel and film derived from peripheral venous blood with tension-free sutures.Buccal keratinized gingival height(preoper-atively,14 d,and 3 mo postoperatively),tooth movement distance,gingival crease(1,2,and 3 mo postoperatively),pain status(VAS at 1 d,3 d,and 7 d postoperatively),and healing status were compared between groups.Postoperative complications were recorded.Results Before and at 14 d/3 mo post-surgery,buccal keratinized gingival height in the control group first decreased then increased,with significant intra-group differences(P＜0.05),while no significant changes occurred in the observation group(P＞0.05).The observation group showed significantly higher gingival height than the control group at 14 d(P＜0.05).At 1,2,and 3 mo post-surgery,buccal and mesial-distal tooth movement distances progressively increased in both groups(P＜0.05),with longer distances in the observation group(P＜0.05).Vertical and parallel probing depths increased over time in both groups(P＜0.05),but were significantly lower in the observation group(P＜0.05).The observation group had a lower cumulative gingival crease incidence at 3 mo(P＜0.05).VAS scores gradually decreased post-surgery in both groups(P＜0.05),with lower scores in the observation group(P＜0.05).Conclusion PRF application in extraction sockets after orthodontic extraction effectively relieves the postoperative pain,promotes the recovery of buccal keratinized gingival height,accelerates the tooth movement,re-duces the occurrence of gingival crease,and demonstrates good safety.关键词
富血小板纤维蛋白/正畸/术后疼痛/牙周组织变化/牙齿移动Key words
Platelet-rich fibrin/Orthodontic extraction/Postoperative pain/Periodontal tissue changes/Tooth movement分类
医药卫生引用本文复制引用
李静,尹俊,郝怡然,李媛媛,蔡世新..富血小板纤维蛋白对正畸拔牙术后疼痛、牙周组织变化及牙齿移动的影响[J].转化医学杂志,2025,14(4):119-124,6.基金项目
衡水市2023年度科技计划项目(2023014036Z) （2023014036Z）
