神经药理学报2025，Vol.15Issue(1)：43-48,6.DOI:10.3969/j.issn.2095-1396.2025.01.007
甘草酸药理作用及其作为药物载体的应用研究进展
Progress in Pharmacological Effects of Glycyrrhizic Acid and Its Application as Drug Carrier
摘要
Abstract
Glycyrrhiza uralensis Fisch is a traditional Chinese medicine with the functions of tonifying spleen and replenishing qi,expelling phlegm and relieving cough,clearing heat and detoxifying,and harmonizing other medicines.Its main active ingredient is Glycyrrhizic acid(GA),which is a triterpenoid saponin compound with antiviral,anti-tumor,anti-inflammatory,liver protection and various pharmacological activities.Glycyrrhizic acid has amphiphilic structure,which can spontaneously form micelles with core-shell structure.GA has the properties similar to surfactants and has good biological stability and solubility.With the progress of nanotechnology,it has become a research hotspot to modify glycyrrhizic acid with nanomaterials or self-assemble it into nanoparticles for the transport of various drugs to overcome the defects of low bioavailability and poor water solubility of drugs.This paper reviews the pharmacological activity and mechanism of glycyrrhizic acid and its application as a multifunctional drug carrier material,so as to provide reference for its further development,utilization and clinical research.关键词
甘草酸/药理活性/自组装Key words
glycyrrhizic acid/pharmacological activity/self-assembly分类
药学引用本文复制引用
郑海新,李婷,殷宏艳,张海红,王树..甘草酸药理作用及其作为药物载体的应用研究进展[J].神经药理学报,2025,15(1):43-48,6.基金项目
河北北方学院科研项目(No.XJ2024023),张家口市重点研发计划项目(No.2421083D) （No.XJ2024023）
