神经药理学报2025，Vol.15Issue(1)：49-54,6.DOI:10.3969/j.issn.2095-1396.2025.01.008
中药调控IL-1β治疗骨关节炎的机制及研究进展
Mechanism and Research Progress of IL-1β Modulation by Traditional Chinese Medicine in the Treatment of Osteoarthritis
摘要
Abstract
Osteoarthritis is a major disabling disease in clinical orthopedics.Osteoarthritis(OA)is a common orthopedic disease characterized by degenerative changes in articular cartilage and increased friction in the joints,leading to joint pain,swelling and deformity.At this stage,studies have shown that a variety of cytokines that cause localized inflammation in the joints are released during the development of osteoarthritis,among which interleukin-1β(IL-1β)is one of the main factors that accelerate the development process of osteoarthritis.Currently,Western medicine has limited methods for treating osteoarthritis,whereas traditional Chinese medicine(TCM)treats osteoarthritis with multi-targets,advantages such as good efficacy and few side effects.In this paper,we summarize the relationship between IL-1β and osteoarthritis,and review the modern research on the intervention of Chinese medicine in the treatment of osteoarthritis with IL-1β in the past five years,in order to lay an experimental foundation for the exploration of the pathological mechanism of osteoarthritis based on IL-1β,and provide a new method and research ideas for the prevention and treatment of osteoarthritis as well as the research and development of related drugs.关键词
中医药/IL-1β/骨关节炎/机制Key words
Chinese medicine/IL-1β/osteoarthritis/mechanism分类
药学引用本文复制引用
郭广宇,邢涛,雷宁波,肖阳,谢嘉树,李盼盼,张志龙,王振鑫..中药调控IL-1β治疗骨关节炎的机制及研究进展[J].神经药理学报,2025,15(1):49-54,6.基金项目
高水平中医药重点学科建设项目(No.zyyzdxk-2023203),甘肃省自然科学基金项目(No.22JR5RA628),甘肃省联合科研基金项目(No.23JRRA1533),厅级科技项目(No.2023GSMPA044、No.SWSQN2023-08) （No.zyyzdxk-2023203）
