中医药学报2025，Vol.53Issue(6)：32-39,8.DOI:10.19664/j.cnki.1002-2392.250114
基于多糖及熵权-TOPSIS的枸杞子药材质量评价
Quality Evaluation of Lycium Barbarum Medicinal Materials Based on Polysaccharides and Entropy Weight-TOPSIS
摘要
Abstract
Objective:To establish a comprehensive quantitative evaluation model for Lycium barbarum medicinal materials based on the polysaccharide content and the Entropy Weight-Technique for Order Preference by Similarity to an Ideal Solution(TOPSIS)model,providing a reference for the quality evaluation of Lycium barbarum medicinal materials and the selection of the best batches.Methods:Multiple batches of Lycium barbarum from different regions were collected and analyzed for polysaccharide extraction yield,monosaccharide composition,total sugar content,protein content,and uronic acid content.After the results were dimensionlessly normalized,the entropy weight-TOPSIS method was applied for comprehensive evaluation,and selection criteria were established.Results:The appearance of the different batches of Lycium barbarum showed no significant differences and conformed to the pharmacopoeia description.However,the yield,monosaccharide composition,and other indicators varied significantly between batches.According to the entropy weight method,total sugar content had the highest weight(29.73%)in the comprehensive evaluation index system,followed by arabinose content(22.50%),uronic acid content(13.74%),and protein content(11.65%).TOPSIS ranking and classification results showed that when the relative closeness(Ci)was≥0.6,the batch of Lycium barbarum was considered a high-quality source for polysaccharide extraction;when 0.5≤Ci<0.6,the batch was considered a medium-quality source;and when Ci<0.5,the batch was considered a low-quality source.Conclusion:Significant differences in polysaccharide quality were found between different batches and regions of Lycium barbarum.The entropy weight-TOPSIS method,based on comprehensive multi-indicator evaluation,enables rapid,efficient,and accurate selection of high-quality Lycium barbarum polysaccharide extracts,with broad applications in production and comprehensive quality evaluation.This method can also serve as a reference for the quality evaluation of other traditional Chinese medicinal materials or decoction pieces.关键词
枸杞子/熵权-逼近理想解排序法(TOPSIS)/质量评价/多糖/糖组成/糖醛酸Key words
Lycium barbarum/Entropy Weight-TOPSIS/Quality evaluation/Polysaccharides/Monosaccharide composition/Uronic acid分类
中医学引用本文复制引用
杨志城,孙彩虹,叶冠..基于多糖及熵权-TOPSIS的枸杞子药材质量评价[J].中医药学报,2025,53(6):32-39,8.基金项目
上海医药中药传承和创新平台能力建设项目(2020006) （2020006）
