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The mechanisms and clinical significance of CD8+T cell exhaustion in anti-tumor immunity

Tao Zhong Shuo Sun Mingsheng Zhao Bin Zhang Huabao Xiong

癌症生物学与医学（英文版）2025，Vol.22Issue(5)：460-480,21.

癌症生物学与医学（英文版）2025，Vol.22Issue(5)：460-480,21.DOI:10.20892/j.issn.2095-3941.2024.0628

The mechanisms and clinical significance of CD8+T cell exhaustion in anti-tumor immunity

Tao Zhong ¹Shuo Sun ²Mingsheng Zhao ¹Bin Zhang ³Huabao Xiong⁴

作者信息

1. Institute of Immunology and Molecular Medicine,Key Laboratory of Cell and Biomedical Technology of Shandong Province,College of Basic Medicine,Jining Medical University,Jining 272067,China
2. College of Life Science,Jining Medical University,Rizhao 276826,China
3. Affiliated Hospital of the Jining Medical University,Jining 272029,China
4. Institute of Immunology and Molecular Medicine,Key Laboratory of Cell and Biomedical Technology of Shandong Province,College of Basic Medicine,Jining Medical University,Jining 272067,China||Affiliated Hospital of the Jining Medical University,Jining 272029,China
折叠

摘要

关键词

CD8+T cell exhaustion/immune checkpoint/immune checkpoint inhibitors/cancer immunotherapy/anti-tumor immunity

Key words

CD8+T cell exhaustion/immune checkpoint/immune checkpoint inhibitors/cancer immunotherapy/anti-tumor immunity

引用本文复制引用

Tao Zhong,Shuo Sun,Mingsheng Zhao,Bin Zhang,Huabao Xiong..The mechanisms and clinical significance of CD8+T cell exhaustion in anti-tumor immunity[J].癌症生物学与医学（英文版）,2025,22(5):460-480,21.

基金项目

This study was supported by grants from the National Natural Science Foundation of China(Grant No.82171810)and the Program of Shandong Provincial Scientific and Technological Development of Traditional Chinese Medicine(Grant No.M-2023210). （Grant No.82171810）

癌症生物学与医学（英文版）

ISSN：2095-3941

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