首页|期刊导航|癌症生物学与医学（英文版）|Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer

Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer

Pei Wang Hai Hu Zhenkun Na Xin Du Zhiren Han Jiaxin Zhong Jiayu Yuan Lin Jiang Beinan Han Wenkui Fu Hongde Li

癌症生物学与医学（英文版）2025，Vol.22Issue(5)：502-524,23.

癌症生物学与医学（英文版）2025，Vol.22Issue(5)：502-524,23.DOI:10.20892/j.issn.2095-3941.2024.0398

Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer

Pei Wang ¹Hai Hu ²Zhenkun Na ³Xin Du ¹Zhiren Han ¹Jiaxin Zhong ¹Jiayu Yuan ⁴Lin Jiang ⁴Beinan Han ¹Wenkui Fu ¹Hongde Li³

作者信息

1. Department of Oncology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China
2. Postgraduate Training Base Alliance of Wenzhou Medical University,Zhejiang Cancer Hospital,Hangzhou 310022,China||Hangzhou Institute of Medicine,Chinese Academy of Sciences,Zhejiang Cancer Hospital,Hangzhou 310018,China||Breast Cancer Center,Zhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou 310022,China
3. Hangzhou Institute of Medicine,Chinese Academy of Sciences,Zhejiang Cancer Hospital,Hangzhou 310018,China
4. Postgraduate Training Base Alliance of Wenzhou Medical University,Zhejiang Cancer Hospital,Hangzhou 310022,China
折叠

摘要

关键词

Breast cancer/tumor-associated macrophages/serine metabolism/polarization

Key words

Breast cancer/tumor-associated macrophages/serine metabolism/polarization

引用本文复制引用

Pei Wang,Hai Hu,Zhenkun Na,Xin Du,Zhiren Han,Jiaxin Zhong,Jiayu Yuan,Lin Jiang,Beinan Han,Wenkui Fu,Hongde Li..Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer[J].癌症生物学与医学（英文版）,2025,22(5):502-524,23.

基金项目

This work was supported by grants from the National Key R&D Program of China(Grant No.2022YFC3401001),National Natural Science Foundation of China(Grant Nos.82025026 and 82230091 to H.H.),Key R&D Program of Zhejiang(Grant No.2024C03160),and GuangDong Basic and Applied Basic Research Foundation(Grant Nos.2023A1515012412 and 2023A1515011214). （Grant No.2022YFC3401001）

癌症生物学与医学（英文版）

ISSN：2095-3941

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