中国肿瘤生物治疗杂志2025，Vol.32Issue(5)：518-524,7.DOI:10.3872/j.issn.1007-385x.2025.05.009
溶酶体相关膜蛋白3与转录激活因子4在宫颈癌中的表达及其临床意义
Expression and clinical significance of lysosome-associated membrane protein 3 and activating transcription factor 4 in cervical cancer
摘要
Abstract
Objective:To investigate the expression of lysosome-associated membrane protein 3(LAMP3)and activating transcription factor 4(ATF4)in cervical cancer and their correlation with clinicopathological parameters.Methods:The expression of LAMP3 and ATF4 in normal cervical tissues,cervical intraepithelial lesions,and cervical cancer tissues was detected by SP immunohistochemistry.The relationships between the expression of these two proteins and patient clinicopathological parameters were analyzed,as well as the correlation between LAMP3 and ATF4 expression.Results:LAMP3 was negative or lowly expressed in both normal cervix tissues and high-grade squamous intraepithelial lesions,but highly expressed in cervical cancer tissues(38.3%),showing a statistically significant difference(χ2=14.113,P=0.001).ATF4 was highly expressed in 26.7%of the normal cervix tissues,10.0%of the high-grade squamous intraepithelial lesions,and 58.3%in the cervical cancer tissues,also showing a significant difference(χ2=11.078,P=0.004).In cervical cancer,LAMP3 expression was significantly associated with FIGO stage(χ2=10.139,P=0.006)and lymph node metastasis(χ2=8.475,P=0.004);ATF4 expression was significantly associated with tumor size(χ2=4.578,P=0.032),FIGO stage(χ2=8.971,P=0.009),and lymph node metastasis(χ2=7.881,P=0.005).There was a positive correlation between the expression of LAMP3 and ATF4 in cervical cancer tissues(r=0.388,P=0.002).Conclusion:LAMP3 and ATF4 are highly expressed in cervical cancer tissues and are positively correlated.Both of them play important roles in the development and progression of cervical cancer and could serve as potential therapeutic targets for cervical cancer treatment.关键词
宫颈癌/溶酶体相关膜蛋白3/转录激活因子4Key words
cervical cancer/lysosome-associated membrane protein 3(LAMP3)/activating transcription factor 4(ATF4)分类
临床医学引用本文复制引用
王亚越,栾晓娜,陈筱涵,马慧慧,李明玉,田甜..溶酶体相关膜蛋白3与转录激活因子4在宫颈癌中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2025,32(5):518-524,7.基金项目
青岛市医药卫生科研指导项目(No.2022-WJZD188) （No.2022-WJZD188）
