北京大学学报（自然科学版）2025，Vol.61Issue(3)：456-464,9.DOI:10.13209/j.0479-8023.2024.106
S100A4和S100A10在小鼠毛囊发育中的表达定位
Expression and Localization of S100A4 and S100A10 in Mouse Hair Follicle Development
摘要
Abstract
In order to study the expression and localization of S100A4 and S100A10 at different time points of skin hair follicle development in C57BL/6N mice,E13.5,E15.5,E18.5 pregnant mouse embryos and P2,P4,P8 newborn mice were selected.Three mice were taken at each time-point.The expression and localization of S100A4 and S100A10 mRNA and proteins in the back skin of mice were detected by molecular biology and histological techniques.The results showed that the mRNA and protein expressions of S100A4 and S100A10 firstly increased and then decreased during the development of hair follicles,and the mRNA and protein expressions were the highest at 2 days after birth.Immunohistochemical localization showed that S100A4 protein and S100A10 protein were continuously expressed in mouse hair follicle development,but their localization regions were different.It is suggested that S100A4 and S100A10 may play an important role in the development of mouse hair follicles.In conclusion,the expression of S100A4 and S100A10 is different in the back skin of mice at different time points of hair follicle development,and S100A4 and S100A10 participate in the development process of mouse hair follicles.关键词
S100A4/S100A10/小鼠/毛囊发育Key words
S100A4/S100A10/mice/hair follicle development引用本文复制引用
白勇将,栗雯华,杨炜峰,崔云丽,叶富豪,侯增耀,庞全海..S100A4和S100A10在小鼠毛囊发育中的表达定位[J].北京大学学报（自然科学版）,2025,61(3):456-464,9.基金项目
国家自然科学基金(31872532,31272628)资助 （31872532,31272628）
