北京大学学报（医学版）2025，Vol.57Issue(3)：423-429,7.DOI:10.19723/j.issn.1671-167X.2025.03.003
基于家系设计的血脂指标的配偶相关性
Spousal correlations of blood lipid based on a family design
摘要
Abstract
Objective:To explore the spousal correlations of total cholesterol(TC),total triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C),and to investigate the reasons behind these spousal correlations.Methods:Participants and data were from the baseline survey of family-based cohort studies in Fangshan,Beijing and Tulou,Fujian.The ori-gin of spousal correlations were explored from perspectives of convergence,assortative mating,social ho-mogamy.Pearson's correlation and generalized linear models(GLM)were used to estimate the spousal correlation.Convergence was assessed by Pearson's correlation between the phenotypic differences be-tween couples and the duration of marriage,with GLM used for further validation.Pearson's correlation of genetic risk scores(GRS)and couple-specific Mendelian randomization(MR)were calculated to assess the genetic correlation and possible causal relationships between spouses.Two-independent-sample t-tests were used to compare GRS consistency across subgroups divided by education attainment,couple-specific MR and Q statistics used to test assortative mating in subgroups and intergroup differences.Results:In the study,342 couples(287 couples from Fangshan and 55 couples from Fujian)were included,with the average age of(64.91±8.76)years.Spousal correlations of TC,TG,HDL-C,and LDL-C showed statistically significant associations both before and after adjusting for covariates,with effect sizes of 0.229(95％CI:0.125-0.327),0.257(95％CI:0.155-0.354),0.179(95％CI:0.074-0.280),and 0.181(95％CI:0.076-0.282).For convergence,for each additional year of marriage,ΔTC increased by 0.016 mmol/L(95％CI:0.001-0.033 mmol/L),and ΔLDL-C increased by 0.017 mmol/L(95％CI:0.002-0.031 mmol/L).For assortative mating,GRS correlations and results of couple specific MR didn't show any statistical significance.For social homogamy,no differences in GRS or assortative mating were found between subgroups stratified by education attainment.Conclusion:The blood lipid in participants exhibit spousal phenotypic correlations,however,no effects of convergence,assortative mating or social homogamy were observed.More independent studies with larger sample sizes are warranted to further validate these findings in the future.关键词
家系研究/配偶相关性/选择性婚配/社会同质性/伴侣间趋同Key words
Family-based study/Spousal concordance/Assortative mating/Social homogamy/Con-vergence分类
医药卫生引用本文复制引用
李奕昕,秦雪英,李劲,叶莺,吴涛,陈大方,胡永华,李立明,郭煌达,彭和香,侯天姣,章涵宇,谭音希,郑一,王梦莹,武轶群..基于家系设计的血脂指标的配偶相关性[J].北京大学学报（医学版）,2025,57(3):423-429,7.基金项目
国家自然科学基金(82204135、82473716)、北京市自然科学基金(7232237)、福建省自然科学基金(2021J01352)和福建省医学创新课题(2024CXA030)Supported by the National Natural Science Foundation of China(82204135,82473716),the Beijing Natural Science Founda-tion(7232237),the Natural Science Foundation of Fujian Province(2021J01352),and the Fujian Provincial Health Technology Project(2024CXA030) （82204135、82473716）
