北京大学学报（医学版）2025，Vol.57Issue(3)：584-591,8.DOI:10.19723/j.issn.1671-167X.2025.03.024
2015-2021年宁波市6岁以下儿童热性惊厥的流行病学特征
Epidemiological characteristics of febrile seizure among children under 6 years old in Ningbo City from 2015 to 2021
摘要
Abstract
Objective:To describe the epidemiological characteristics and changes of febrile seizure(FS)among children under 6 years old in Ningbo City,Zhejiang Province from 2015 to 2021.Methods:Based on the Ningbo Regional Health Information Platform,a dynamic cohort was established using vacci-nation registration information,and the cases of FS were identified by the diagnostic results of Chinese terms or International Classification of Diseases 10th revision(ICD-10)R56.0 code in the electronic medical records.The first visit of FS during the observation period was defined as a new case,and a re-currence case was defined as the case with a visit interval of more than 7 days.The 95％confidence in-terval(CI)of FS incidence density was calculated by the Poisson distribution.Results:From January 2015 to June 2020,there were 1.3 million children under 6 years old in Ningbo,with male accounting for 52.87％.The median follow-up time was 2.83(1.55-4.00)years.During the follow-up period,12 776 new onset cases had FS,with more males than females,with an overall incidence density of 4.34(95％CI:4.27-4.40)/1 000 person-years and a recurrence rate of 21.63％.There was a higher inci-dence density in children who were male,born in Ningbo and of non-mobility.The incidence density of FS was higher in urban areas than in rural and rural-urban fringe areas,and the incidence density was different among districts and counties.The peak density was found in children aged 18-23 months[8.42(95％CI:8.11-8.74)/1 000 person-years].From 2015 to 2019,the incidence density in-creased with calendar year(Ptrend＜0.001),and the highest was 5.62(95％CI:5.43-5.81)/1 000 person-years.The incidence density of FS decreased significantly during the period between 2020 and 2021.The incidence density was higher in winter.Conclusion:From 2015 to 2019,the overall inci-dence density of FS in children under 6 years old in Ningbo City presented an increasing trend.More at-tention should be paid to the health education,the improvement of the health maintenance model,the en-hancement of the cognition of FS,the identification and treatment of FS among high-risk population and regions so as to prevent its recurrence and reduce the disease burden during the corona virus disease 2019(COVID-19)epide-mic.关键词
热性惊厥/发病密度/流行特征/动态队列/儿童Key words
Febrile seizures/Incidence density/Epidemiological characteristics/Dynamic cohort/Children分类
临床医学引用本文复制引用
刘光旭,刘志科,詹思延,张良,赵厚宇,邓思危,杨君婷,李宁,马瑞,何艳,许国章..2015-2021年宁波市6岁以下儿童热性惊厥的流行病学特征[J].北京大学学报（医学版）,2025,57(3):584-591,8.基金项目
国家自然科学基金(91846303)和中国中医药循证医学中心研究室主任专项(2020YJSZX-2)Supported by the National Natural Science Foundation of China(91846303)and the Special Project for Director,China Center for Evidence Based Traditional Chinese Medicine(2020YJSZX-2) （91846303）
