国际医药卫生导报2025，Vol.31Issue(12)：前插3,1938-1942,6.DOI:10.3760/cma.j.cn441417-20250117-12001
高血压脑出血患者血清GFAP和HSP47水平变化及其与神经功能的关系
Changes of serum levels of GFAP and HSP47 in patients with hypertensive intracerebral hemorrhage and their relationship with neurological function
摘要
Abstract
Objective To study and explore the changes of serum levels of glial fibrillary acidic protein(GFAP)and heat shock protein 47(HSP47)in patients with hypertensive intracerebral hemorrhage and their relationship with neurological function.Methods One hundred and twenty-four patients with hypertensive intracerebral hemorrhage treated in No.215 Hospital of Shaanxi Nuclear Industry from June 2023 to June 2024 were selected for the retrospective study.There were 62 male cases and 62 female cases,with an age of ≥18 years old.According to the scores of modified Rankin Scale(mRS)evaluated within one month after the hospitalization treatment,they were divided into a good prognosis group(the score of mRS 0-3,76 cases)and a poor prognosis group(the score of mRS 4-6,48 cases).The gender,bleeding site,smoking history,drinking history,diabetes,hyperlipidemia,operation method,blood routine,and other indicators of the two groups were collected.The levels of GFAP,HSP47,interleukin(IL)-6,and neuron-specific enolase(NSE)and bleeding volumes were compared between the two groups.The correlation of prognosis with GFAP and HSP47 was analyzed.The impact of GFAP and HSP47 on their prognosis was analyzed.The sensitivities and specificities of GFAP and HSP47 in predicting their prognosis were explored.The rank sum test and x2 test were used for the statistical comparisons.The correlation of prognosis with GFAP,HSP47,IL-6,NSE,bleeding volume,and score of Glasgow Coma Scale(GCS)were analyzed by the Spearman correlation analysis.The receiver operating characteristic curve was used to analyzed the efficacies of the indicators in the evaluation of the patients' prognosis.Results The levels of GFAP,HSP47,IL-6,and NSE and bleeding volume in the good prognosis group were lower than those in the poor prognosis group,and the score of GCS was higher,with statistical differences(all P＜0.05).The prognosis was positively correlated with GFAP,HSP47,IL-6,NSE,and bleeding volume(r=0.499,0.388,0.479,0.736,and 0.491;all P＜0.001),and negatively with the score of GCS(r=-0.775;P＜0.001).The areas under the curves of GFAP and HSP47 in the prediction of the prognosis were both greater than 0.7,indicating that both had certain diagnostic efficacy(both P＜0.05).GFAP,HSP47,NSE,and bleeding volume were risk factors for prognosis,and the score of GCS a protective factor.Conclusions The serum levels of GFAP and HSP47 are related to neurological function in patients with hypertensive intracerebral hemorrhage.The higher the levels of GFAP and HSP47,the worse their neurological function.Both are risk factors for evaluating patients with hypertensive intracerebral hemorrhage.关键词
高血压脑出血/胶质纤维酸性蛋白/热休克蛋白47/神经功能/预后/相关性Key words
Hypertensive intracerebral hemorrhage/Glial fibrillary acidic protein/Heat shock protein 47/Neurological function/Prognosis/Correlation引用本文复制引用
李林,杨杰,翟海燕,祝丽芳,张潇..高血压脑出血患者血清GFAP和HSP47水平变化及其与神经功能的关系[J].国际医药卫生导报,2025,31(12):前插3,1938-1942,6.基金项目
国家自然科学基金(82271317) National Natural Science Foundation(82271317) （82271317）
