国际医药卫生导报2025，Vol.31Issue(12)：1943-1947,5.DOI:10.3760/cma.j.cn441417-20250102-12002
AIS大脑中动脉闭塞患者血清清蛋白、miR-134及mCTA侧支循环评分的临床意义
Significance of albumin,miR-134,and mCTA collateral circulation score in patients with cerebral artery occlusion after AIS
摘要
Abstract
Objective To evaluate the value of serum albumin,microRNA(miR)-134,and multi-temporal computed tomography angiography(mCTA)collateral circulation score for prognosis of patients with cerebral artery occlusion after acute ischemic stroke(AIS).Methods The medical records of 124 patients with middle artery occlusion after AIS admitted to Yulin Xingyuan Hospital from June 2022 to June 2024 were retrospectively analyzed.The were 42-72 years old.They were divided into a mild to moderate group(59 cases)and a severe group(65 cases)according to the scores of the National Institutes of Health Stroke Scale(NIHSS).According to the scores of the modified Rankin scale(mRS)90 d after the onset,the patients were divided into a poor prognosis group(mRS score＞2;46 cases)and a good prognosis group(mRS Score ≤2;78 cases).The serum levels of microRNA-134 and albumin and mCTA collateral circulation scores were compared between the patients with different disease severities and prognoses.t and x2 tests were used for the statistical comparisons.The receiver operating characteristic curve(ROC)was used to analyze the efficacy of each indicator in the prediction of the patients' prognosis.Results The serum levels of microRNA-134 and albumin and mCTA collateral circulation score in the severe group were(34.13±6.34)g/L,4.60±0.93,and 3.11±0.58,and those in the the mild to moderate group were(40.29±5.80)g/L,2.58±0.41,and 3.90±0.35,with statistical differences(all P＜0.05).The serum levels of microRNA-134 and albumin and mCTA collateral circulation score in the poor prognosis group were(35.55±5.94)g/L,4.13±0.75,and 3.28±0.51,and those in the good prognosis group were(39.62±6.33)g/L,2.81±0.57,and 3.84±0.40,with statistical differences(all P＜0.05).The ROC analysis showed that the areas under the curves of serum albumin,miR-134,and mCTA collateral circulation score in predicting the patients' prognosis were 0.708,0.766,0.807,and 0.896,respectively.Conclusions Patients with middle cerebral artery occlusion after AIS who have poor prognosis have higher a serum microRNA-134 level,a lower albumin level,and a lower mCTA collateral circulation score;these indicators have high predictive value for the patients' prognosis.关键词
清蛋白/微小核糖核酸-134/多时相计算机断层扫描血管成像/侧支循环评分/急性缺血性脑卒中/预后Key words
Albumin/MicroRNA-134/Multi-temporal computed tomography angiography/Collateral circulation score/Acute ischemic stroke/Prognosis引用本文复制引用
李建军,蒋锋,刘小丽..AIS大脑中动脉闭塞患者血清清蛋白、miR-134及mCTA侧支循环评分的临床意义[J].国际医药卫生导报,2025,31(12):1943-1947,5.基金项目
陕西省自然科学基础研究计划(2022JM-594) Basic Research Plan of Natural Science in Shaanxi(2022JM-594) （2022JM-594）
