国际医药卫生导报2025，Vol.31Issue(12)：1948-1952,5.DOI:10.3760/cma.j.cn441417-20241106-12003
奥拉西坦联合阿司匹林及氯吡格雷对TIA疗效及神经修复功能的影响
Effect of oxiracetam combined with aspirin and clopidogrel for patients with TIA and its influence on neurological repair function
摘要
Abstract
Objective To explore the effect oxiracetam combined with aspirin and clopidogrel for patients with transient ischemic attack(TIA)and its influence on neurological repair function.Methods A total of 100 patients with TIA admitted to Department of Neurology,Xi'an Daxing Hospital from March 2021 to March 2024 were selected for the randomized controlled trial.They were divided into a control group and an oxiracetam group by the method of drawing lots from envelopes,with 50 cases in each group.There were 29 males and 21 females in the control group;they were(63.87±5.84)years old;their disease course was(1.57±0.35)d;18 cases had lesions on the vertebrobasilar artery,and 32 cases on the internal carotid artery.There were 31 males and 19 females on the oxiracetam group;they were(63.74±5.71)years old;their disease course was(1.62±0.42)d;15 cases had lesions on the vertebrobasilar artery,and 35 cases on the internal carotid artery.The control group took aspirin and clopidogrel,and the oxiracetam group took oxiracetam,aspirin,and clopidogrel.The clinical efficacies and neurological repair function,relevant scores,laboratory indicators,and oxidative stress levels before and after the treatment were compared between the two groups by t and x2 tests.Results After the treatment,the total effective rate in the oxiracetam group was higher than that in the control group[94.0％(47/50)vs.80.0％(40/50);P＜0.05].The levels of insulin-like growth factor-1,brain-derived neurotrophic factor,and nerve growth factor in the oxiracetam group were higher than those in the control group[(25.25±2.92)g/L vs.(22.45±2.53)g/L,(39.17±4.47)μg/L vs.(33.77±4.13)μg/L,and(189.37±25.45)ng/L vs.(170.12±22.38)ng/L;all P＜0.05].The levels of monocyte chemoattractant protein-1,tumor necrosis factor-α,and matrix metalloproteinase in the oxiracetam group were lower than those in the control group[(136.64±15.18)μg/L vs.(150.75±18.24)μg/L,(7.36±0.90)μg/L vs.(9.75±1.11)μg/L,(95.78±10.71)ng/L vs.(117.12±13.85)ng/L;all P＜0.05].The levels of superoxide dismutase,nitric oxide,and glutathione peroxidase in the oxiracetam group were higher than those in the control group[(83.53±8.28)U/L vs.(77.52±7.82)U/L,(83.25±3.25)μmol/L vs.(74.67±3.31)μmol/L,and(92.72±6.13)U/L vs.(85.68±5.21)U/L;all P＜0.05].The scores of the Montreal Cognitive Assessment Scale,Mini-Mental State Examination,and Modified Barthel Index in the oxiracetam group were higher than those in the control group(27.10±3.14 vs.24.76±2.82,23.45±2.85 vs.21.13±2.43,and 53.56±7.45 vs.49.97±6.56),and the score of the National Institutes of Health Stroke Scale was lower(12.69±1.44 vs.15.78±1.52)(all P＜0.05).Conclusion Oxiracetam combined with aspirin and clopidogrel for patients with TIA is effective and has a significant impact on their neurological repair function.关键词
奥拉西坦/阿司匹林/氯吡格雷/短暂性脑缺血发作/神经功能Key words
Oxiracetam/Aspirin/Clopidogrel/Transient ischemic attack/Neurological function引用本文复制引用
郑春利,刘蕾,杨伟毅..奥拉西坦联合阿司匹林及氯吡格雷对TIA疗效及神经修复功能的影响[J].国际医药卫生导报,2025,31(12):1948-1952,5.基金项目
陕西省自然科学基础研究计划(S2024-JC-YB-2232) Basic Research Plan of Natural Science in Shaanxi(S2024-JC-YB-2232) （S2024-JC-YB-2232）
