国际医药卫生导报2025，Vol.31Issue(12)：2033-2038,6.DOI:10.3760/cma.j.cn441417-20241120-12021
基于TGF-β1/Smads信号通路探讨金匮肾气丸联合氯沙坦钾片对老年糖尿病肾病患者肾脏纤维化指标的影响
To investigate effect of Jinkui Shenqi pills combined with chlorosartan potassium tablets on renal fibrosis indicators in elderly patients with diabetic nephropathy based on TGF-β1/Smads signal pathway
摘要
Abstract
Objective To investigate the effect of Jinkui Shenqi pills combined with chlorosartan potassium tablets on renal fibrosis indicators in elderly patients with diabetic nephropathy of the yin-yang deficiency type based on the transforming growth factor-β1(TGF-β1)/Smads signal pathway.Methods A total of 110 elderly patients with diabetic nephropathy of the yin-yang deficiency type treated at Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from January 2023 to January 2024 were selected for the randomized controlled trial,and were divided into a control group and an observation group by the random number table method,with 55 cases in each group.There were 29 males and 26 females in the observation group;they were(68.59±5.48)years old;their disease course was(2.14±0.72)years.There were 32 males and 23 females in the control group;they were(69.25±5.74)years old;their disease course was(2.37±0.68)years.The control group took chlorosartan potassium tablets and conventional treatment;in addition,the observation group took Jinkui Shenqi pills.Both groups were treated continuously for 2 months.The scores of Chinese medicine symptoms,blood glucose levels[fasting blood glucose(FBG)and 2-hour postprandial blood glucose(2hPBG)],levels of renal function indicators[blood urea nitrogen(BUN),serum creatinine(SCr),and 24-hour urinary protein(24hUpro)],levels of renal fibrosis indicators[connective tissue growth factor(CTGF),procollagen type Ⅲ(PC Ⅲ),laminin(LN),and collagen type Ⅳ(C Ⅳ)],and protein and mRNA expressions of TGF-β1,Smad2,Smad3,and Smad7 were compared between the two groups before and after the treatment.The clinical efficacies and incidence rates of adverse reactions were compared between the two groups.t and x2 tests were used for the statistical analysis.Results Before the treatment,there were no statistical differences in the score of traditional Chinese medicine symptoms,levels of FBG,2hPBG,BUN,SCr,24hUpro,LN,PC Ⅲ,C Ⅳ,and CTGF,and protein and mRNA expressions of TGF-β1,Smad2,Smad3,and Smad7 between the two groups(all P＞0.05).After the treatment,the scores of traditional Chinese medicine symptoms,levels of FBG,2hPBG,BUN,SCr,24hUpro,LN,PC Ⅲ,C Ⅳ,and CTGF,and protein and mRNA expressions of TGF-β1,Smad2,and Smad3 were lower than those before the treatment in both groups,and those in the observation group were lower than those in the control group(all P＜0.05).After the treatment,the protein and mRNA expressions of Smad7 were higher than those before the treatment in both groups,and those in the observation group were higher than those in the control group(all P＜0.05).The total clinical effective rate of the observation group was higher than that of the control group[92.73％(51/55)vs.72.73％(40/55);x2=7.698;P＜0.05].There was no statistical difference in the total incidence rate of adverse reactions between the two groups(x2=0.440;P＞0.05).Conclusion Jinkui Shenqi pills combined with chlorosartan potassium tablets in the treatment of elderly patients with diabetic nephropathy of the yin-yang deficiency type is effective,which may improve their clinical symptoms and renal function inhibiting the expression of the TGF-β1/Smads signal pathway,and reduce the degree of renal fibrosis.关键词
糖尿病肾病/TGF-β1/Smads信号通路/金匮肾气丸/氯沙坦钾片/阴阳两虚型/肾脏纤维化Key words
Diabetic nephropathy/TGF-β1/Smads signal pathway/Jingui Shenqi pills/Chlorosartan potassium tablets/Yin-yang deficiency type/Renal fibrosis引用本文复制引用
秦刚新,苏衍进,赵莉,王惠铃,杨锦欣..基于TGF-β1/Smads信号通路探讨金匮肾气丸联合氯沙坦钾片对老年糖尿病肾病患者肾脏纤维化指标的影响[J].国际医药卫生导报,2025,31(12):2033-2038,6.基金项目
陕西省重点研发计划(2020SF-336) Key Plan of Research and Development in Shaanxi Province(2020SF-336) （2020SF-336）
