国际医药卫生导报2025，Vol.31Issue(12)：2046-2051,6.DOI:10.3760/cma.j.cn441417-20250109-12023
解郁疏肝汤加减治疗多囊卵巢综合征(肝郁肾虚证)的效果分析
Effect analysis of Jieyu Shugan Decoction in treating polycystic ovary syndrome(liver-stagnation and kidney deficiency syndrome)
摘要
Abstract
Objective To analyze the effect of Jieyu Shugan Decoction on polycystic ovary syndrome(liver-stagnation and kidney deficiency syndrome).Methods A retrospective analysis was conducted.A total of 101 patients with polycystic ovary syndrome(liver-stagnation and kidney deficiency syndrome)admitted to Baoji Maternal and Child Health Hospital during January 2022 to December 2023 were selected and divided into a control group and an observation group based on different treatment methods.The control group received oral cyproterone acetate and ethinyl estradiol tablets,while the observation group received the same tablets plus modified Jieyu Shugan Decoction.The control group consisted of 50 patients with age of(29.67±3.52)years and disease duration of(3.31±0.64)years.The observation group consisted of 51 patients with an average age of(30.43±3.64)years and an average disease duration of(3.48±0.73)years.Both groups were treated continuously for 12 weeks.The clinical efficacy,adverse reactions,and changes in traditional Chinese medicine(TCM)symptom scores,serum hormone levels[follicle stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH),testosterone(T),anti-mullerian hormone(AMH)],and uterine artery hemodynamics[pulsatility index(PI)and resistance index(RI)]were compared between the two groups.Statistical analysis was performed using t and x2 tests.Results After treatment,the total effective rate of treatment in the observation group was higher than that in the control group[94.12％(48/51)vs.78.00％(39/50)],and the difference was statistically significant(P＜0.05).The TCM syndrome score,serum LH,T,and AMH levels,PI,and RI in the observation group were all lower than those in the control group[(8.61±2.13)points vs.(14.52±3.27)points,(9.05±1.37)IU/L vs.(11.16±1.52)IU/L,(0.92±0.17)pmol/L vs.(1.11±)]0.23)pmol/L,(7.29±1.14)μg/L vs.(9.46±1.37)μg/L,2.16±0.26 vs.2.52±0.39,0.62±0.11 vs.0.73±0.10](t=10.783,12.026,12.534,15.904,5.468,5.256,all P＜0.05),andthelevelsofserumFSHandE2werebothhigher[(5.91±0.61)IU/L vs.(5.64±0.57)IU/L,(204.62±23.57)ng/L vs.(165.38±16.82)ng/L];the differences were all statistically significant(all P＜0.05).The total occurrence of adverse reactions in the observation group showed no statistically significant difference compared with that in the control group[7.84％(4/51)vs.10.00％(5/50),P＞0.05].Conclusion Jieyu Shugan Decoction in the treatment of polycystic ovary syndrome(liver-stagnation and kidney deficiency syndrome)can improve the therapeutic effect,alleviate symptoms,regulate serum hormone levels,and improve endometrial blood flow state,without increasing the occurrence of adverse reactions.关键词
多囊卵巢综合征/解郁疏肝汤/肝郁肾虚证Key words
Polycystic ovary syndrome/Jieyu Shugan Decoction/Liver-stagnation and kidney deficiency syndrome引用本文复制引用
张朝红,刘妍,雷静,姜丽丽,刘兰,胡雅平..解郁疏肝汤加减治疗多囊卵巢综合征(肝郁肾虚证)的效果分析[J].国际医药卫生导报,2025,31(12):2046-2051,6.基金项目
陕西省重点研发计划(2023-YBSF-492) Shaanxi Provincial Key Research and Development Program(2023-YBSF-492) （2023-YBSF-492）
