广东药科大学学报2025，Vol.41Issue(3)：1-10,10.DOI:10.16809/j.cnki.2096-3653.2025033101
司美格鲁肽可溶性微针的制备与评价
Preparation and evaluation of Semaglutide dissolving microneedles
摘要
Abstract
Objective To optimize the microneedle matrix material and dosage by a one-way test in order to construct an ideal transdermal delivery system for Semaglutide soluble microneedles.Methods A multi-step vacuum-injection molding method was utilised to prepare Semaglutide soluble microneedles,with the moldability,needle content and mechanical properties serving as the evaluation indexes.The composition and amount of the matrix materials and the amount of Semaglutide were optimised by a one-way test to evaluate the appearance,mechanics,penetration,dissolution,and in vitro transdermal permeation properties.Concurrently,a content determination method was established.Results Microneedles composed of a blend of trehalose(3%),PVA(20%),and Semaglutide(0.4%)had a four-pronged conical tip,with a needle length of(658.03±1.61)μm,a tip distance of 736.38 μm,and a needle content of(98.37±0.68)%.The mechanical strength of the material was found to be(2.25±0.02)N.It was observed that the microneedles underwent complete dissolution within 10 mins of afeter puncturing the skin,and the puncture depth was about 635 μm,with a puncture efficiency of(94.22±1.33)%.The cumulative 24 h penetration of semaglutide microneedles was 3-fold higher compared to the solution,thereby demonstrating the efficacy of the content method in accordance with the established requirements.Conclusion This delivery system has been demonstrated to effectively penetrate the stratum corneum,thereby facilitating the dissolution and release of the drug substance into the skin.This finding provides a compelling foundation for the painless delivery of Semaglutide.关键词
司美格鲁肽/可溶性微针/多步真空-注模法/海藻糖/聚乙烯醇Key words
Semaglutide/soluble microneedle/multi-step vacuum-mold injection method/trehalose/polyvinyl alcohol分类
药学引用本文复制引用
黄咏彤,谢欣言,时军,王纠..司美格鲁肽可溶性微针的制备与评价[J].广东药科大学学报,2025,41(3):1-10,10.基金项目
广东省自然科学基金项目(2022A1515011382) （2022A1515011382）
