国际医药卫生导报2025，Vol.31Issue(12)：2073-2077,5.DOI:10.3760/cma.j.cn441417-20240805-12028
不同参数1 565 nm非剥脱点阵激光治疗增生性瘢痕的疗效
The efficacy of 1 565 nm non-ablative fractional laser treatment with different parametexs for hypertrophic scars
摘要
Abstract
Objective To investigate the efficacy of 1 565 nm non-ablative fractional laser treatment with different parameters on hypertrophic scars and its impact on growth factors.Methods A prospective study was conducted from May 2020 to June 2023 involving 62 patients with hypertrophic scars treated at Yulin Hospital,First Affiliated Hospital of Xi'an Jiaotong University.The patients were divided into two groups using a random number table method.In Group A,there were 15 males and 16 females;the laser parameters were set as follows:energy 30 mJ and density 200 spots/cm2;the age was(25.85±4.54)years old,and the disease duration was(2.98±1.36)years.In Group B,there were 16 males and 15 females;the laser parameters were set as follows:energy 45 mJ and density 200 spots/cm;the age was(26.52±4.18)years old,and the disease duration was(3.02±1.30)years.Both groups were treated once a month for three consecutive months.The clinical indicators,scar scores before and after treatment,serum growth factor levels,and adverse reaction rates were compared between the two groups.Statistical analysis was performed using t-tests and x2 tests.Results After treatment,there were no statistically significant differences in the times for edema and erythema resolution between the two groups[(2.59±0.48)d vs.(2.72±0.43)d and(4.72±1.25)d vs.(5.07±1.29)d],with no statistically significant differences(both P＞0.05).However,the Vancouver Scar Scale(VSS),Observer Scar Assessment Scale(OSAS),and Patient Scar Assessment Scale(PSAS)scores were significantly lower in Group B compared to Group A[(3.42±0.74)points vs.(4.31±0.82)points,(21.46±3.62)points vs.(24.68±3.47)points,and(19.36±3.21)points vs.(21.75±3.13)points,respectively,with t-values of 4.486,3.575,and 2.968,all P＜0.05].The post-treatment serum levels of vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),and transforming growth factor-β1(TGF-β1)were lower in Group B than in Group A[(185.43±51.64)ng/L vs.(212.96±52.83)ng/L,(179.35±49.71)ng/L vs.(205.35±50.24)ng/L,and(243.21±48.78)ng/L vs.(275.64±52.46)ng/L],with statistically significant differences(t=2.075,2.048,and 2.521,all P＜0.05).There were no statistically significant differences in the incidence rate of adverse reactions such as skin itching,pigmentation,and blisters[96.77％(30/31)vs.93.55％(29/31),P＞0.05].Conclusions The 1 565 nm non-ablative fractional laser is highly effective in treating hypertrophic scars.The scar scores(including OSAS and PSAS scores)and serum growth factor(VEGF,EGF,and TGF-β1)levels in the high-energy(45 mJ)treatment group were significantly lower than those in the low-energy(30 mJ)treatment group.Therefore,the high-energy setting of the 1 565 nm non-ablative fractional laser can be an effective choice for treating hypertrophic scars.关键词
增生性瘢痕/1 565nm非剥脱点阵激光/生长因子Key words
Hypertrophic scars/1 565 nm non-ablative fractional laser/Growth factors引用本文复制引用
马彬溪,王应权,马云云,朱振来..不同参数1 565 nm非剥脱点阵激光治疗增生性瘢痕的疗效[J].国际医药卫生导报,2025,31(12):2073-2077,5.基金项目
陕西省自然科学基础研究计划(2024JC-YBMS-645) Shaanxi Provincial Natural Science Basic Research Program(2024JC-YBMS-645) （2024JC-YBMS-645）
