广东药科大学学报2025，Vol.41Issue(3)：29-35,7.DOI:10.16809/j.cnki.2096-3653.2024112601
多潘立酮纳米混悬剂的制备及质量评价
Preparation and quality evaluation of Domperidone nanosuspension
摘要
Abstract
Objective To optimize the preparation process of Domperidone nanosuspension stabilized with glycyrrhizic acid and evaluate its in vitro and in vivo properties.Methods Using Domperidone as a model drug,Domperidone nanosuspension was prepared by the anti-solvent precipitation method;the formulation process was optimized through orthogonal experiments,followed by physicochemical characterization of the resultant nanosuspension;the in vitro release of Domperidone nanosuspension was measured using the dialysis bag method;freeze-drying method was used for solidification,and particle size and polydispersity index were used as evaluation indicators to screen freeze-drying protectants;the gastrointestinal motility experiment of mice was carried out to investigate the effect of Domperidone nanosuspension on gastrointestinal motility.Results The particle size of the Domperidone nanosuspension was approximately 160 nm,with a spherical morphology,and it demonstrated good stability over a period of 30 days.The Domperidone in the nanosuspension exhibited an amorphous state,with a solubility of 59.6 µg/mL.It demonstrated a high cumulative release rate of 93.92%in simulated gastric fluid over 24 h and significantly enhanced gastrointestinal motility in mice.Conclusion Domperidone nanosuspension can effectively improve the solubility of Domperidone.关键词
多潘立酮/纳米混悬剂/甘草酸/反溶剂沉淀法Key words
Domperidone/nanosuspension/glycyrrhizic acid/anti-solvent precipitation method分类
药学引用本文复制引用
颜利,王树玉,张吉梅,刘金叶,郑燕燕,崔媛媛,毕研平,郝吉福,何玉静..多潘立酮纳米混悬剂的制备及质量评价[J].广东药科大学学报,2025,41(3):29-35,7.基金项目
国家自然科学基金项目(82003677) （82003677）
山东省自然科学基金项目(ZR2020QH352、ZR2024MH097) （ZR2020QH352、ZR2024MH097）
山东第一医科大学学术推广计划项目(2019LJ0030) （2019LJ0030）
山东第一医科大学(山东省医学科学院)临床-基础联合创新团队项目(202401) （山东省医学科学院）
